…a fully powered trial and not as a feasibility study. But recruitment for the trial apparently proved difficult, the intervention group experienced high attrition, and the results were disappointing. Why…
…more than declare the trial to be “profoundly flawed.” In his comments, he touched on one of the main negative consequences of the PACE debacle–the fact that the trial and/or…
…trial registration, swapped outcome measures after gathering data from early trial participants, and failed to disclose these salient details in the published paper. However, we are surprised you believe addressing…
…his 25 years doing trials with leading trialists and statsticians [sic] and asked about my own clinical trial experience. I don’t care how many years Professor Sharpe has worked with…
…two journals, in the following Virology Blog posts: https://www.virology.ws/2017/12/13/trial-by-error-the-smile-trials-undisclosed-outcomes/ https://www.virology.ws/2018/01/30/trial-by-error-a-letter-to-archives-of-disease-in-childhood/ https://www.virology.ws/2017/08/28/trial-by-error-no-ethical-review-of-crawley-school-absence-study/ https://www.virology.ws/2018/02/19/trial-by-error-a-letter-to-bmj-open/ I have cc’d Fiona Godlee, editor-in-chief of The BMJ and editorial director of BMJ Company, on this e-mail….
…in response to that: 1) A trial can be “the largest” and still be crap. 2) Professor Crawley and her team did not read this important trial document carefully enough…
