Reassortment of the influenza virus genome
Mutation is an important source of RNA virus diversity that is made possible by the error-prone nature of RNA synthesis. Viruses with segmented genomes, such as influenza virus, have another…
Search Results for: Trial by Error
Detecting viruses: the plaque assay
…units (PFU) per milliliter. To determine the virus titer, the plaques are counted. To minimize error, only plates containing between 10 and 100 plaques are counted, depending on the size…
Pandemic H1N1 influenza virus outcompetes seasonal strains in ferrets
…“superbug” as some researchers had feared. Virologists consider mutation and reassortment to be two distinct phenomena. The mutation rate of the virus is determined by error-prone RNA synthesis. The host…
What if influenza virus did not reassort?
…error-prone RNA replication. Long before the laboratory-engineered strain circled the globe, mutations would likely occur that restore its ability to undergo reassortment. There is at least one practical use for…
Inside the outbreaks
…of Clinical Investigation. *Author Mark Pendergrast and former EIS officer Patrick Moore have reminded me that Gerberding was not a member of this training program. My apologies for the error….
Viral bioinformatics: Multiple sequence alignment €“ Base-By-Base (BBB) editor
…can be very useful when you need to edit an assembled/annotated sequence for an occasional sequencing error.Figure 1A. Differences between sequences are high-lighted. Blue=nt substitution; Green=nt deletion; Red=nt insertion. Figure…