Virology
TWiV Special: Vincent Munster on MERS-coronavirus and Ebolavirus
By Vincent Racaniello | | This Week in Virology
At the Rocky Mountain Laboratory in Hamilton, Montana, Vincent speaks with Vincent Munster about the work of his laboratory on MERS-coronavirus and Ebolaviruses. You can find this TWiV Special at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiVspecialmunster.mp3″] Click arrow to play Download TWiV Special (34 MB .mp3, 56 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
TWiV 427: It was a DURC and UV light
By Vincent Racaniello | | This Week in Virology
The TWiVoids discuss the March for Science, the GOF moratorium, and a classic virology paper on mapping the gene order for vesicular stomatitis virus. You can find TWiV #427 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV427.mp3″] Click arrow to play Download TWiV 427 (59 MB .mp3, 98 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Prions in bacteria
By Vincent Racaniello | | Information
Bacteria do not develop transmissible spongiform encephalopathies, but they have been found to produce prions – proteins that can adopt alternative conformations with different functions. Prion diseases, a frequent topic on this blog, are caused by misfolding of a normal cellular prion protein (illustrated; image copyright ASM Press). Prion proteins are found in other organisms, where the alternative conformation …
TWiV 426: I’m Axl, and I’ll be your cervid today
By Vincent Racaniello | | This Week in Virology
The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. You can find TWiV #426 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV426.mp3″] Click arrow to play Download TWiV 426 (66 MB .mp3, 110 min) Subscribe …
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Communication between virus-infected cells
By Vincent Racaniello | | Basic virology, Information
You might recall learning in high school biology that bacteriophage infection of a host can lead to either replication and cell lysis, or integration of the viral genome into the host (illustrated). The latter event, called lysogeny, spares the host from virus induced killing. For some phages, the decision between lysis and lysogeny appears to be communicated …
TWiV 425: All picornaviruses, all the time
By Vincent Racaniello | | This Week in Virology
The TWiVaniellos discuss a thermostable poliovirus empty capsid vaccine, and two cell genes that act as a switch between entry and clearance of picornavirus infection. You can find TWiV #425 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV425.mp3″] Click arrow to play Download TWiV 425 (65 MB .mp3, 107 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
David Tuller
Trial By Error: Video of October Talk in Ireland on How “Biopsychosocial” Research on ME, Long Covid, and Related Illnesses Harms Patients
By David Tuller, DrPH In October, I spent 10 days traveling around Ireland and giving a talk called “Bad Science, Bad Medicine: How Flawed Biopsychosocial Studies on ME, Long Covid, etc Harm Patients.” (I wrote about the trip here.) I came as a guest of the Irish ME/CFS Association, which had previously arranged similar tours …
Trial By Error: Some Things I’ve Read Recently–Long Covid and Fertility Issues, Psychotherapy Ethics, How to Fake Your Results
By David Tuller, DrPH It’s been a slow period. Here are a few things I’ve read recently… “The pandemic’s untold fertility story” While Long Covid disproportionately affects women, its impact on their reproductive lives has not received the attention the issue deserves. Recently, Australia’s ABC News addressed the issue with a moving piece called “The …
Trial By Error: Cochrane Continues Telling ME/CFS Patients to Go F–k Themselves
By David Tuller, DrPH Update/Correction: Below, I initially wrote that Cochrane was lying in describing the update plan as a “pilot project.” However, it turns out that the organization did describe its plan to engage community partners as a “pilot project.” Here’s the statement from March, 2020: “Cochrane is conducting a pilot project for engaging …
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Trial By Error: Cochrane Tells ME/CFS Patients to Go F–k Themselves
By David Tuller, DrPH Cochrane has just given the finger to the international ME/CFS community. After jerking everyone around and promising for five years to conduct a new review of exercise interventions for the illness, the organization abruptly abandoned that commitment this week. On Monday, Cochrane posted the following message on its website: “In 2019, …
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Trial By Error: Agencies Respond to Coroner’s Report in Boothby O’Neill Inquest
Update: Maeve’s mum, Sarah Boothby, has commented on this blog. I am posting her comment here: Sorry if this seems picky but Maeve did not die in hospital [DT: Fixed! Not sure how I made this error] and the RDUH Trust document is what we call a treatment pathway. It is the first of its …
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Trial By Error: Letter to BMJ Editor Seeking Correction in New Review of Interventions for Long Covid
By David Tuller, DrPH The BMJ recently published a review of interventions for Long Covid that–surprise!–recommended CBT and a rehabilitation program as treatments. The review is full of holes. I have focused on one in particular. The review relies for its rehabilitation recommendation on an earlier BMJ study–even though that study has itself already been …