Twenty-five lectures in virology for 2017

Every year I teach a virology course to undergraduates and masters students at Columbia University. I record video and audio of each of the twenty-five lectures and release them on YouTube – so that not only the students but the rest of the world can learn about the amazing field of virology. With the spring …

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Trial By Error, Continued: The CMRC Affirms Full Support for Libelous Esther

By David Tuller, DrPH For the last couple of weeks, I have been hammering the CFS/ME Research Collaborative to take a position on the actions of its deputy chair, Libelous Esther, better known as Dr. Esther Crawley. As I reported in several previous posts, Dr. Crawley falsely accused me of writing libelous blogs and Dr. …

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TWiV 441: Don’t ChrY for me influenza

The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse – the Y chromosome regulates their susceptibility to influenza virus infection. You can find TWiV #441 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 441 (72 MB .mp3, 119 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

Flu and the Y chromosome

Disease and death caused by influenza virus are greater in human females than in males. But disease is more common in males from birth through age 15, after which more females are affected. In mice, genetic variation in the Y chromosome controls susceptibility to influenza virus infection (link to paper). Increased susceptibility does not correlate …

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Trial By Error, Continued: CMRC to Virology Blog: F**k Off!

by David Tuller, DrPH Well, not in those words, of course. It was all very polite. But that was the message. Here’s what happened. On Monday, I posted an open letter to the members of the board of the CFS/ME Research Collaborative. The letter involved the false accusation of libel that the CMRC’s deputy chair, …

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Trial By Error, Continued: An Open Letter to the Board of the CFS/ME Research Collaborative

by David Tuller, DrPH To Members of the Board of the CMRC: Not long ago, at the annual conference of the British Renal Society, your deputy chair disseminated the false accusation that I had libeled her. As a corollary to that, she also disseminated the false accusation that Dr. Racaniello, the Columbia University microbiologist who …

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Trial By Error: Yet Again BMJ Recommends CBT and Exercise for Long Covid

By David Tuller, DrPH What is going on at The BMJ? In May, the journal corrected an obvious error in a paper about a prominent Long Covid mental and physical rehabilitation trial called REGAIN. The trial was conducted among patients who had been hospitalized for Covid-19, but key sections of the paper generalized the findings …

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Trial By Error: Canadian Group Seeks Feedback on Recommendations for Exercise and CBT for Long Covid

By David Tuller, DrPH A group called Canadian Guidelines for Post COVID-19 Condition (CAN-PCC) has released a new set of draft recommendations related to preventing, diagnosing and treating what is commonly called Long Covid. The current list of nine draft recommendations includes exercise and cognitive behavior therapy, which has understandably raised concerns among advocates for …

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Trial By Error: Interview with Karen Hargrave, Co-Founder of #ThereForME

By David Tuller, DrPH Karen Hargrave is co-founder of an advocacy campaign called #ThereForME, which was launched this past summer to draw public awareness to the UK’s lack of care and treatment and to call “for an NHS [National Health Service] that’s there for people with ME and Long Covid.” The campaign has drawn significant …

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Trial By Error: My Letter to BMJ Seeking Correction to Editorial on REGAIN Trial of Mental-and-Physical-Health Rehab for Long Covid

By David Tuller, DrPH I have recovered sufficiently from my post-election coma to send off another of my irritating letters to journals–this one to The BMJ. As I mentioned in a post earlier this week, The BMJ has corrected a major paper: “Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme …

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Trial By Error: Professor Chris Ponting on “Replicated Blood-Based Biomarkers” for ME in Big Data Pre-Print Study

By David Tuller, DrPH Along with several colleagues, Professor Chris Ponting, a geneticist at the University of Edinburgh and a leading ME/CFS researcher, recently posted a pre-print called “Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity.”  (A pre-print is a paper that has not yet been formally peer-reviewed.) For this analysis, the investigators …

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Trial By Error: The BMJ Corrects REGAIN Study’s Expansive Claims; Results Only Applicable to Post-Hospitalized Long Covid Patients

By David Tuller, DrPH In February, The BMJ published a study called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial.” (Post-Covid-19 Condition, or PCC, is one of many current definitions for Long Covid.)The study, led by a team from …

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