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Once Again, Lancet Stumbles on PACE

Last February, Virology Blog posted an open letter to The Lancet and its editor, Dr. Richard Horton, describing the indefensible flaws of the PACE trial of treatments for ME/CFS, the disease otherwise known as chronic fatigue syndrome (link to letter). Forty-two well-regarded scientists, academics and clinicians put their names to the letter, which declared flatly …

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TWiV 403: It’s not easy being vaccine

The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, and a new adjuvanted subunit zoster vaccine. You can find TWiV #403 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV403.mp3″] Click arrow to play Download TWiV 403 (70 MB .mp3, 96 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

TWiV 402: The plight of the bumblebee

Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV. You can find TWiV #400 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV402.mp3″] Click arrow to play Download TWiV 402 (85 MB .mp3, 118 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

Do giant viruses have a CRISPR-like immune system or a protein restriction factor?

A battle is brewing between two research groups in Marseille, France that are involved in the discovery and study of giant viruses. Didier Raoul and colleagues believe that they have discovered a CRISPR-like, DNA based defense system in mimivirus that confers resistance to virophage (paper link). Claverie and Abergel disagree: they think that the defense …

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Interview with J. Michael Bishop

A major new feature of the fourth edition of Principles of Virology is the inclusion of 26 video interviews with leading scientists who have made significant contributions to the field of virology. For the chapter on Transformation and Oncogenesis, Vincent spoke with Nobel Laureate J. Michael Biship, of the University of California, San Francisco, about his career and his work on oncogenes.

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