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When viruses cross species, serial transmission may lead to the selection for mutations that confer improved replication or transmission in the new host. Identifying such mutations in human viruses is extremely difficult: we cannot conduct the appropriate experiments in humans, and often do not have viral isolates spanning the time from spillover through prolonged circulation. The 2013-2016 outbreak …

Increased infectivity of Ebola virus glycoprotein from West Africa Read More »

by David Tuller, DrPH David Tuller is academic coordinator of the concurrent masters degree program in public health and journalism at the University of California, Berkeley. ‘The PACE trial is a fraud.’ Ever since Virology Blog posted my 14,000-essord investigation of the PACE trial last October, I’ve wanted to write that sentence. (I should point …

Trial By Error, Continued: The Real Data Read More »

Last October, Virology Blog posted David Tuller’s 14,000-word investigation of the many flaws of the PACE trial (link to article), which had reported that cognitive behavior therapy and graded exercise therapy could lead to “improvement” and recovery from ME/CFS. The first results, on “improvement,” were published in The Lancet in 2011; a follow-up study, on …

No ‘Recovery’ in PACE Trial, New Analysis Finds Read More »

Professor Simon Gaskell President and Principal Queen Mary University of London Mile End Road London E1 4NS Dear Professor Gaskell: Last month, the First-Tier Tribunal ordered Queen Mary University of London to release critical data from the PACE trial of treatments for chronic fatigue syndrome, also known as myalgic encephalomyelitis, or ME/CFS. In its decision, …

Open letter to Queen Mary University of London about PACE Read More »

By David Tuller, DrPH In January, I posted a list of the questions I still wanted to ask the PACE authors, who have repeatedly refused my requests to interview them about their ethically and methodologically challenged study. Richard Horton, editor of The Lancet, has similarly declined to talk with me, ignoring my e-mails seeking comment …

Trial By Error, Continued: My Questions for Lancet Editor Richard Horton Read More »