Trial By Error: When Primary Outcomes Yield Null Results in Clinical Trials, FND Experts Prefer Their Secondary Outcomes
By David Tuller, DrPH In 2020, the CODES study of cognitive behavior therapy (CBT) for psychogenic non-epileptic seizures, also known as dissociative seizures, reported null findings for its primary outcome—the number of seizures per month one year after the start of therapy. This was a disappointing result for an ambitious effort to seek an effective …
