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Trial By Error: When Primary Outcomes Yield Null Results in Clinical Trials, FND Experts Prefer Their Secondary Outcomes

By David Tuller, DrPH In 2020, the CODES study of cognitive behavior therapy (CBT) for psychogenic non-epileptic seizures, also known as dissociative seizures, reported null findings for its primary outcome—the number of seizures per month one year after the start of therapy. This was a disappointing result for an ambitious effort to seek an effective …

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Trial By Error: Australian GPs Keep Promoting Exercise Treatments for ME/CFS

By David Tuller, DrPH When it comes to treatments for ME/CFS, the Royal Australian College of General Practitioners (RACGP) has long endorsed the graded exercise therapy (GET)/cognitive behavioral therapy (CBT) approach. Last April, the organization published an “updated” article in its Handbook of Non-Drug Interventions (HANDI) advocating “incremental physical activity” for what it called CFS/ME. …

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Trial By Error: Andrew Ewing & David Joffe on Just-Published “Global Expert Consensus” on Long Covid

By David Tuller, DrPH *This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120 Last week, the journal Annals of Clinical Microbiology and Antimicrobials published the results of …

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Trial By Error: #MEAction’s Jaime Seltzer on Where We’ve Been, What We’ve Learned, and Where Things Are Now

By David Tuller, DrPH *This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120 It’s been five years, more or less, since the start of the coronavirus pandemic–and …

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Trial By Error: In a Compelling Documentary, Five Doctors Discuss Being Sick

By David Tuller, DrPH *This is a crowdfunding period at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120 ********** I first connected with Anil van der Zee, a severe ME patient in …

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Trial By Error: Null Results in Physiotherapy Trial for Functional Motor Disorder

By David Tuller, DrPH *This is a crowdfunding month at University of California, Berkeley. If you appreciate my work and would like to make a donation (tax-deductible to US taxpayers) to the university in support of my position, here’s the link: https://crowdfund.berkeley.edu/project/46120 It must be tough for investigators when a major study seeking to assess the …

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