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The AstraZeneca/Oxford University Phase 3 COVID-19 Vaccine Trial €“ Why Was It Paused?

by Helen Stillwell Recently, a Phase 3 trial investigating a COVID-19 vaccine (AZD1222) being developed by AstraZeneca and the University of Oxford was put on hold in the US following a report of an adverse event in a study participant in the U.K. (Feuerstein 2020). One of the predominant vaccine candidates against SARS-CoV-2, AZD1222 is …

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Longevity of SARS-CoV-2 memory B cells

Immunity conferred by influenza virus vaccine is short-lived. After immunization with inactivated influenza virus vaccine, serum antibody levels peak within a few months and then decline rapidly. This decline was recently shown to be caused by loss of bone marrow plasma cells, a major source of serum antibodies. Results of a recent study partially address …

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Pandemics and anthropogenic environmental change

All human viruses have their origin in a virus that crossed from a different animal species. The encounters that lead to these spillovers are driven by explosive human population growth and incredible change occurring in all ecosystems brought about by human occupation of almost every corner of the planet. The extent to which land-use change …

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