Virology lecture #18: HIV pathogenesis
Download: .wmv (330 MB) | .mp4 (72 MB) Visit the virology W3310 home page for a complete list of course resources.
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Inhibition of XMRV by a weapon of mass deamination
All mammalian genomes contain genes encoding Apobec proteins. Several members of this protein family (the name stands for apolipoprotein B mRNA editing complex) are induced by interferon and are intrinsic antiretroviral proteins. Apobec proteins inhibit the replication of XMRV, a new human retrovirus associated with prostate cancer and chronic fatigue syndrome. During retroviral replication, Apobec …
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Virology lecture #17: Acute infections
Download: .wmv (322 MB) | .mp4 (91 MB) Visit the virology W3310 home page for a complete list of course resources.
Futures in Biotech 58: The Vertical Farm
I joined Marc Pelletier on episode 58 of Futures in Biotech for a conversation with Dickson Despommier. We talked about some of Dickson’s passions – eukaryotic parasites and vertical farming. The idea for placing hydroponic farms in skyscrapers, about to be realized, was conceived by one of Professor Despommier’s classes at Columbia University. Video courtesy …
Poliovirus vaccine, SV40, and human cancer
Deep sequencing – which identified a viral contaminant of the rotavirus vaccine Rotarix – could have revealed the presence of simian virus 40 (SV40) in the poliovirus vaccine, had the technique been available in the 1950s. Exposure of over 100 million Americans to SV40, and many more worldwide, could have been avoided, as well as the debate …
Poliovirus vaccine safety
The contamination of the rotavirus vaccine Rotarix with porcine circovirus 1 DNA was revealed by deep sequencing. The same technique was also used to demonstrate that oral poliovirus vaccine does not contain viruses that can cause poliomyelitis. The oral poliovirus vaccine strains developed by Albert Sabin (pictured) were licensed in the United States in 1962, …