Virology lecture #17: Acute infections
Download: .wmv (322 MB) | .mp4 (91 MB) Visit the virology W3310 home page for a complete list of course resources.
Basic virology
Virology lecture #16: Persistent infections
Download: .wmv (331 MB) | .mp4 (68 MB) Presented by guest lecturer Saul Silverstein, Ph.D. Visit the virology W3310 home page for a complete list of course resources.
Poliovirus vaccine, SV40, and human cancer
Deep sequencing – which identified a viral contaminant of the rotavirus vaccine Rotarix – could have revealed the presence of simian virus 40 (SV40) in the poliovirus vaccine, had the technique been available in the 1950s. Exposure of over 100 million Americans to SV40, and many more worldwide, could have been avoided, as well as the debate …
Poliovirus vaccine safety
The contamination of the rotavirus vaccine Rotarix with porcine circovirus 1 DNA was revealed by deep sequencing. The same technique was also used to demonstrate that oral poliovirus vaccine does not contain viruses that can cause poliomyelitis. The oral poliovirus vaccine strains developed by Albert Sabin (pictured) were licensed in the United States in 1962, …
Inhibitors of XMRV
Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). Because XMRV is a retrovirus, it might be susceptible to antiviral drugs that are licensed for the treatment of AIDS. AZT (azidothymidine) was previously found to block XMRV replication. A screen of forty-five compounds reveals that XMRV …
Virology lecture #14: Virus-host interactions
Download: .wmv (343 MB) | .mp4 (94 MB) Visit the virology W3310 home page for a complete list of course resources.