Basic virology

The Lazarus virus

There is an excellent question in the comments to “Are all virus particles infectious?“: if the particle-to-PFU ratio for a virus stock is 10,000:1, and I infect 1,000,000 cells with 10,000 particles, how many plaques would I expect to observe? Answering this question provides insight into the particle-to-PFU ratio of viruses. If we take 10,000 particles …

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David and Goliath: How one cytokine may take down influenza

This article was written for extra credit by a student in my virology course. by Alexandra Jacunski Recent research has suggested a new method of flu prevention and treatment: the administration of granulocyte macrophage-colony stimulating factor (GM-CSF) to the lungs of mice significantly reduced flu symptoms and prevented mortality after a lethal dose of influenza virus. …

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Gut microbes influence defense against influenza

The bacteria in our intestines outnumber by tenfold the 100 trillion cells that comprise the human body. This gut microbiota has many beneficial functions, including the production of vitamins and hormones, fermentation, regulation of gut development, and shaping intestinal immune responses. They also play a role in pathological conditions such as diabetes and obesity, and …

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Women AND men beware: HPV, the culprit behind more than just cervical cancers?

This article was written for extra credit by a student in my virology course. by Bethany DiPrete Human papillomavirus (HPV) infection is the most common sexually transmitted disease in the United States, and as of yet, there is no cure.  However, there is a vaccine to prevent infection by certain strains. Recent research may encourage not …

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