The classical complement pathway begins when the initiator protein C1q binds directly to the surface of a pathogen, or to an antibody that is bound to a microbe. There is a binding site for C1q on the Fc portion of antibody molecules. C1q can also recognize molecular patterns characteristic of pathogens, much like the Toll-like receptors. C1q binding …
During the more than 30 years that I have studied viruses, I have had many opportunities to speak with journalists of different kinds. For the most part, the print journalists have done a good job at accurately presenting the science, but I cannot say the same for my experience on radio and TV. I want …
The complement system is a collection of blood and cell surface proteins that is a major primary defense and a clearance component of innate and adaptive immune responses. At least 30 different complement proteins act sequentially to produce a wide ranges of activities, from cell lysis to augmentation of the adaptive response. The complement system …
Hosts: Vincent Racaniello, Dick Despommier, and Alan Dove On episode #52 of the podcast “This Week in Virology”, Vincent, Dick, and Alan (with a cameo appearance by Rich Condit) review the world’s largest Phase III study of a complex HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak …
Influenza A viruses tend to garner most of the attention, but let’s not forget that there are two other virus types, B and C. The enveloped influenza A virions have three membrane proteins (HA, NA, M2), a matrix protein (M1) just below the lipid bilayer, a ribonucleoprotein core (consisting of 8 viral RNA segments and …
Hosts: Vincent Racaniello and Jason Rodriguez On episode #50 of the podcast “This Week in Virology”, Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV050.mp3″] Click …
