October 2014

Enterovirus D68 infections in North America

An outbreak of respiratory disease caused by enterovirus D68 began in August of this year with clusters of cases in Missouri and Illinois. Since then 691 infections have been confirmed in 46 states in the US. The number of confirmed infections is likely to increase in the coming weeks, as CDC has developed a more rapid diagnostic …

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Combination antiviral therapy for hepatitis C

The Food and Drug Administration has approved the use of a single pill containing two different antiviral drugs for the treatment for hepatitis C. It is the first combination pill approved for the disease, and also the first treatment that does not contain interferon or ribavirin. The new hepatitis C drug, called Harvoni, is a mixture …

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TWiV 306: This Week in Ebolavirus

On episode #306 of the science show This Week in Virology, the Grand Masters of the TWiV discuss Ebola virus transmission, air travel from West Africa, Ebola virus infectivity on surfaces, the Dallas Ebola virus patient, and Ebola virus in dogs. You can find TWiV #306 at www.microbe.tv/twiv.

Treatment of Ebola virus infection with brincidofovir

The Liberian man who was diagnosed with Ebola virus infection after traveling to Dallas, Texas, was treated with an antiviral drug called brincidofovir. This drug had originally been developed to treat infections with DNA-containing viruses. Why was it used to treat an Ebola virus infection? Brincidofovir (illustrated) is a modified version of an antiviral drug …

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Oral polio vaccine-associated paralysis in a child despite previous immunization with inactivated virus

Vaccine-associated poliomyelitis caused by the oral poliovirus vaccine is rare, but its occurrence in a healthy, immunocompetent 6-month old child was highly unusual because the child had been previously immunized with two doses of the injected, inactivated poliovirus vaccine (IPV). The three poliovirus vaccine strains developed by Albert Sabin (OPV, oral poliovirus vaccine) contain mutations which prevent …

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