Adjuvant effect on H1N1 vaccine

There has been a great deal of discussion about the use of adjuvants to improve the immunogenicity of vaccines against the 2009 H1N1 pandemic influenza strain. What effect do these compounds have on the immune response?

Adjuvants are compounds added to vaccines that stimulate the immune response. They are often used when the antigen is in short supply, or does not induce a good antibody response. Because the 2009 H1N1 pandemic influenza strains do not replicate well in eggs, it has been suggested that adjuvants be used to ensure that there is sufficient supply of vaccine.

A recent study demonstrates very clearly the effect of adjuvants on the immune response. Mice were immunized with egg-produced 2009 H1N1 influenza vaccine with or without the adjuvant MF59. A boost inoculation was given on day 21. Sera were taken on days 13 and 21 and the antibody response was measured by hemagglutination-inhibition (HI) assay. If you don’t know how an HI assay works, please read my previous description. The results of the assay are shown in the figure.

h1n1-adjuvant

One week after immunization with 0.5 micrograms of antigen, the average serum HI titer was 1:15 (bars labeled post1). This titer is barely higher than obtained when mice were immunized with buffer alone (PBS). The HI titer rose to 1:160 after the boost. When MF59 adjuvant was included, the first and second HI titers were significantly higher – 1:63 and 1:1280.

What do thes numbers mean? Protection of humans against seasonal influenza is generally believed to require a HI titer of 1:40 or more. Therefore when MF59 adjuvant is used in mice, one immunization is sufficient to confer protection against disease. Without adjuvant, two doses are required for protection.

Trials are ongoing in adults to determine the immunogenicity of 2009 H1N1 vaccines with and without adjuvant.

I know that many readers are concerned about the possible side effects of adjuvants. MF59 has been used for 12 years in seasonal influenza vaccines in Europe and is considered a safe adjuvant. However, the Centers for Disease Control and Prevention believes that the 2009 H1N1 vaccine will likely not be used with adjuvant.

Dormitzer, PR, Rappuoli, R, Casini, F, Wack, A et al (2009). Adjuvant is necessary for a robust immune response to a single dose of H1N1 pandemic flu vaccine in mice PLoS Currents: Influenza

103 thoughts on “Adjuvant effect on H1N1 vaccine”

  1. I am sorry, but you are mistaken about Japan's experience with vaccines and SIDS. It seems to stem from the sources you used, I suggest you look up “Scopie's Law.”

    There was a concern that the whole-cell pertussis vaccine was causing SIDS, so they suspended vaccination. But then the numbers of infant deaths from pertussis increased, and they could not be blamed on the vaccine. It is detailed in Acellular pertussis vaccines in Japan: past, present and future.:

    An antivaccine movement developed in Japan as a consequence of increasing numbers of adverse reactions to whole-cell pertussis vaccines in the mid-1970s. After two infants died within 24 h of the vaccination from 1974 to 1975, the Japanese government temporarily suspended vaccinations. Subsequently, the public and the government witnessed the re-emergence of whooping cough, with 41 deaths in 1979. This series of unfortunate events revealed to the public that the vaccine had, in fact, been beneficial. Furthermore, researchers and the Japanese government proceeded to develop safer pertussis vaccines. Japan now has the most experience worldwide with acellular pertussis vaccines, being the first country to have approved their use. This review describes the major events associated with the Japanese vaccination program. The Japanese experience should be valuable to other countries that are considering the development and use of such vaccines.

  2. Christopher-Peter: Maingot

    Well…I think it's more a question on where you want to look, for your information, and who you would rather believe. I am not going to expect any vaccine manufacturer to concede anytime soon, that their injected drugs are causing people debilitating health effects, or even death…right?
    I recognize the information that you are quoting, in your reply to me, because I've seen that point of view, and it's an argument that's being put forth by pro-vaccine activists. I will not agree, that; “vaccines have in fact been beneficial.” Why should there have been a need to “develop safer pertussis vaccines”? It all depends on where your minds is at, and, your beliefs. You are obviously a pro-vaccine individual, and you look for mostly pro-vaccine information, to keep you satisfied that it's good. I personally think that there has always been too much of that. In fact as a society, we are saturated with it, either from the government agencies, who depend on Big Pharma for political support, and of course via the MSM especially the television. Next time you're watching the tube, pay attention of how many PHARMA Ads come on during the course of the programming. They pay for and support most all the major networks…right?
    But consider this paradox: Are you…Dying for protection against death?
    You can read the full article via the provided link…look for it in the comments section.
    http://snardfarker.ning.com/profiles/blogs/top-

  3. I really don't know what to think about this vaccine. My granddaughter's boyfriend got the h1n1 shot about 3 weeks ago. I don't know if it had an adjuvant in it or not. Right now he is very sick with a dry cough, body aches, and fever. It came on very sudden, during the night. He is in
    his twenties, so he should have had a good immune response to the shot. But I don't think he did. We live in the US, and he got his shot at the hospital where he works. I'm an RN, and I am not sure what to do! I might be giving these shots at clinics soon.

  4. Christopher-Peter: Maingot

    Rest assured [pgreeneRN], and not just by me, because I am saying so now, but by the facts; there are millions of others who are in the same boat as you, me included. But, it does not mean that we are lost in the fog, or that the boat is leaking and that we are going down with it. Remember; the “EXPERTS” thought it best, that they would not require the full compliment of lifeboats, because — TITANIC would not sink.
    How else are you expected to react, especially when the experts: FDA, CDC, WHO, and GOVERNMENTS, themselves don’t even know what to think about this vaccine, from one day to the next.

    One shot or two, or perhaps three…boosters or no boosters…adjuvanted or non-adjuvanted for pregnant (expecting mothers)…high risk groups or low risk groups…every one should get vaccinated, or loose your job, it’s a state of emergency, and we might even force you to, take OUR DRUGS…if you’re healthy, stay away from the clinics…get my POINT!

    It you could find out which vaccine your granddaughter's boyfriend had it would be easy to determine if it was or it wasn’t (adjuvanted). In my opinion, I think every one should be demanding full disclosure, to know what they are being administered (DRUGS), not just now (VACCINES) but always. It only makes sense; should an adverse reaction occur, at least you can tell the EMS that they had this, or they had that…you know?

    One thing for sure, it that he has had an immune response from the DRUGS…unfortunately, only time will tell whether it is good or bad…I will include him in my prayers, that he will recover without any adverse conditions.

    It is your God given right to refuse the SHOT if you want too. And, it is not acceptable or justified that they should threaten anyone with taking away their means of livelihood for having their own beliefs and opinions…that’s communistic, and shameful, that they would use the word PANDEMIC, to implement party policy.

    I would not intend to leave you more desperate than before, so bear this in mind; being that you are medically trained, you of all people, should be doing your research, and remembering, that there is always three sides (truths) to any story.

    The following is something for all to consider, and it should be more cause for wonder: What’s going on with this entire (H1N1) program?

    Fluzone (Influenza Virus Vaccine) – Initial US Approval: 1980
    Suspension for Intramuscular Injection – 2009-2010 Formula.

    Each 0.25 mL dose contains 7.5 mcg of influenza virus hemagglutinin (HA) and each 0.5 mL dose contains 15 mcg HA of each of the following 3 viruses: A/Brisbane/59/2007, IVR-148 (H1N1), A/Uruguay/716/2007, NYMC X-175C (H3N2) (an A/Brisbane/10/2007-like virus) , and B/Brisbane/60/2008. (3, 11)

    Did you notice (above) the ingredient (H1N1) in this “SEASONAL FLU VACCINE?

    Sanofi Pasteur – Fluzone Influenza Virus Vaccine Information.
    http://www.fda.gov/downloads/BiologicsBloodVacc

    Please watch the video presentation series: Swine Flu Interview with Dr. Blaylock
    http://www.youtube.com/watch?v=Dq2YVnwEnBw

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  5. You are wrong H1N1 is a subtype of influenza A virus , SwineFlu virus is a swine origin H1N1 subtype, it is not the same thing, you are reading it wrong.
    Note: I am a molecular biologist and biochemist

  6. You are wrong H1N1 is a subtype of influenza A virus , SwineFlu virus is a swine origin H1N1 subtype, it is not the same thing, you are reading it wrong.
    Note: I am a molecular biologist and biochemist

  7. The non-adjuvanted Canadian vaccine is as effective as the US version, but made by a different company. The AS03 adjuvant has been studied in children; see a later post in this blog concerning the release of the Canadian vaccine. The side effects are more pronounced in children (injection site pain, fever, for example) hence two half doses are recommended.

  8. I'm not censoring any of your comments, or anyone else's. Apparently the content in your posts is such that my blog software is flagging it as spam. I will do my best to restore the posts.

  9. The US vaccine has no adjuvant. Period. As you know, association is not the same as causation. If I put my shoes on in the morning, and it rains, does that mean putting the shoes on caused it to rain? When millions of people get vaccines, illness will happen soon after which would have occurred whether or not the vaccine was given. Remember, the vaccine stimulates an immune response, which can be associated with fevers and aches; it can vary in severity from one person to another. It means that the vaccine is working.

  10. Those who wish to read conspiracy and malice into all facets of life will ignore facts and use their misunderstanding to further their cause. There are many varieties of H1N1 influenza viruses, some swine-origin, some not. The seasonal H1N1 included in the vaccine noted above is, as you indicate, very different from the 2009 swine-origin H1N1 virus.

  11. Christopher-Peter: Maingot

    OZdy…I'm not sure why I'm wrong, or why you say that I'm reading it wrong.
    [Note: I am a molecular biologist and biochemist]
    Your note; really does nothing to help distinguish what I'm wrong about.

    I agree that H1N1 is a subtype of influenzavirus A…strains of H1N1 however, can also dwell or be native to humans, likewise in swine…would you agree with that?

    Here is another example…this time, it's GSKs Influenza Virus Vaccine FLUARIX® 2008-2009 Formula. http://www.scribd.com/doc/19856004/Fluarix-Pack

    Just like the Fluzone by Sanofi Pasteur, they are using the same A/Brisbane/59/2007 (H1N1)-like virus

    Here is another example, this time by Novartis…See page 4 – Available data show that children 9 years of age and younger, are largely serologically naïve to the pandemic (H1N1) 2009 virus (15.1). Based upon these data Influenza A (H1N1) 2009 Monovalent Vaccine should be administered. http://www.scribd.com/doc/20426192/Novartis-a-H

    The one component that's missing from this discussion however…perhaps you, given your background and obvious expertize, will elaborate and explain in layman's terms can all understand is; most of the 2009 pandemic vaccines which have since become available, contain the BIRD FLU component H5N1…why is that?

    Could this be, just the proverbial ounce of prevention?

    Please watch this presentation…click on the link provided to be re-directed to the video.
    http://vimeo.com/7298827

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  12. I'm glad I found a scientific discussion about this issue.
    But it is still very confusing; it is being said that the H1N1 vaccine in US contains Squalene and Mercury. The side effects of these two components have been discussed extensively and basically talk about Autism, Gillian Barr(?) disease, among others. I'd love to read your thoughts about this.

    Also, I just talked to a pathologist in Mexico City and he believes that the size of the “swine flu problem” that is being given by the goverments is totally out of proportion. He said that the H1N1 virus has proved not to be as deadly as the initial statistics shown. Pharmaceutical companies are certainly benefiting from this whole issue. What is your honest scientific view about this?

  13. The US inactivated flu vaccine does not contain squalene. That's a component of the AS03 adjuvant used in the Canadian vaccine. Mercury is only present as thimerosal in multi-dose vaccine vials. There is no link between either component and autism or Guillain-Barré syndrome. Multiple studies involving many children have shown this. As for the 'swine flu problem', the fact that few people have immunity to this new strain makes it more dangerous than seasonal flu. Even if the mortality rate is the same as seasonal flu, because many more people will be infected means that many will die. Individuals under 30, pregnant women, and those with certain medical conditions are at risk. Of course pharmaceutical companies benefit, as they do by selling many other therapeutics. But the public also benefits because infectious diseases are avoided.

  14. There is an awful lot of media and internet rumour about the immunisations, but the facts are this:

    There are two swine flu vaccines which have been licenced by the EU. One being Pandemrix, the other Calvepan.

    Both vaccines contain dead virus which your body's immune system then produces antibodies to. If you are subsquently exposed to the swine flu virus, your immune system already has the antibodies to fight it off.

    Pandemrix contains an adjuvant called squalene, which assists the immune system in producing antibodies. Many vaccines utilise adjuvants other than squalene.

    The only other vaccine to use squalene as an adjuvant is Fluad. Thishas been used in Italy over the past 10 years. Only given to vaccinate those over the age of 65, so far 22 million doses have been given apparently without serious side effect.

    Squalene is a naturally occuring substance, present in both humans, and animals. The apparent concern is that when injected it can increase the risk of triggering auto immune disorders. These effects have been previously noted in animal vaccines. The other concern is reportedly during the Gulf war, soldiers were given anthrax vaccines which supposedly contained squalene, though this has since been denounced as false.

    So, the facts are a) Squalene is a relatively untested addition to the Pandemrix vaccine
    b) The only known subjects to have received squalene containing vaccines are the over 65 age group
    c) There is a non-adjuvant vaccine (Calvepan), but the NHS is not utilising it
    d) The USA does not licence squalene as a adjuvent
    e) The ordinary season flu vaccines given each autumn do not contain adjuvants

    So draw your own conclusions! I think so much of modern life anyway is full of chemicals, from the fumes we inhale, cosmetics, and pesticides etc that this probably won't make a significant difference to our already unnatural lifestyles.

  15. Does anyone have a current estimate of the immune response from a single 0.25mL dose of adjuvented H1N1 Arepanrix vaccine given to children 7 yrs old and younger? Is a second dose necessary?

  16. Christopher-Peter

    I would like to urge everyone here, especially the more educated ones, in the study of microbiology, virology, immunology, medicine, etc, etc, to listen to the interview between Dr. Mercola and Dr. Larry Palevsky is a board-certified pediatrician trained at the New York School of Medicine…he compellingly and convincingly, provides sound, rational, scientific justification, as to why, you need to seriously reconsider the wisdom of choosing vaccines as an option to prevent against most diseases.

    Expert Pediatrician Discusses Vaccines (Part 1)
    http://www.youtube.com/watch?v=K2IgLj2If44

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  17. Christopher-Peter

    For loladitka, Freda, et al…

    Here is some more information, and it clearly states that the FDA did, find Squalene in the Anthrax vaccines used to vaccinate many soldiers…during the Gulf War/Desert Shield/Storm theater of operations.

    I also read and, have to agree, that some creative measures were put into play to otherwise, try and explain, and perhaps, more importantly for some, dispel the findings of the Squalene, in those actual anthrax vaccine lots, which were, discovered to contain it.

    Stop poisoning our troops with untested vaccines.
    http://www.youtube.com/watch?v=jSL6cd6aOs8

    Beyond Treason
    http://beyondtreason.com/

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  18. Hi there, my physician says the adjuvanted vaccine in Canada provides cross-immunity to mutations of H1N1 virus but not the the unadjuvanted one. I'm trying to decide which one to give to my 16 month old son. He also said the immunity won't be as good with the unadjuvanted one even after two doses! Does this mean many kids in his age group are not well protected in the states because there is no adjuvanted vaccine there? Is the Canadian population better protected against mutations of this virus? Thank you.

  19. Christopher-Peter

    Did you not read in the Canadian news recently…They're dumping a bunch of VACCINES, supposedly because of expiry dates and refrigeration issues, and, bla, bla, bla.
    The stuff that they are getting rid of, is the vaccine formula with the adjuvant added???

    Listen to the interview between Dr. Mercola and, Dr. Larry Palevsky via the link I posted, above this…do your physician a big favour and send him a copy of it too.

    As of November 12, 2009, the PUBLIC HEALTH AGENCY of CANADA, reports a total of 61 deaths, having occurred from swine flu, in Ontario. It may however, still be reasonable to question whether all the deaths are directly attributable to the swine flu (H1N1).

    In order to keep things in a more manageable perspective, and thus hopefully reduce some of the stresses, caused by this pandemic, I have created a few simple statistics based on some reports.

    The 61 Ontario H1N1 deaths, are; said to have had, a start date of April this year. This translates to almost nine deaths per month.

    Now, lets re-visit some other statistics of death, and to which are associated, with just one city in Ontario…Toronto.

    In the year 2000, a report that was conducted and released by the Toronto public health department (TPHD) and titled: “Air Pollution Burden of Illness in Toronto” concluded that 1000 people die every year, prematurely, and, its due to air pollution (poisoning).

    In the year 2004, a similar study was again carried out by TPHD, but this time; it indicated that there was an increase in these premature deaths, to a new estimated total of 1700 every year.

    These numbers, conservatively equate to an increase of 175 new deaths per year. And, to further break down the numbers to a monthly value, would mean, 15 new deaths per month, over the course of the 48 months, between the two studies.

    It may therefore be safe, and, conservative again, to assume that 2500 people, are perhaps now dying every year, from illnesses due to poor air quality. This estimate will therefore, further translate to the staggering amount of 215 deaths per month, simply from drawing life's breath, while living to death in Toronto.

    Dr. Perry Kendall, a British Columbia health officer, is hopeful and, believes, due to specific evidence, that the H1N1 (Swine Flu) virus has peaked, in his province.

    In categorizing the depth of this pandemic: Dr. Richard Schabas, Ontario's former chief medical officer; “believes this one to be a dud.”

    Reports filed just last week, are now showing that $1.5 Billion dollars was so far spent, for the swine flu response in Canada. Ultimately, this has all been due to the World Health Organization, and its redefinition, or establishing of their “new Pandemic criteria.”

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  20. Christopher-Peter

    Dr. David Butler-Jones, Canada's chief public health officer, said today; reported adverse reactions to the H1N1 vaccine, the vast majority of which, have been mild cases of fever, sore arms and allergic reactions, will be made available on the website of the Public Health Agency of Canada. The reactions have included one death, potentially from anaphylaxis, he said.
    All adverse reactions are linked to the version of the vaccine that contains an adjuvant, a chemical additive that stretches supply and boosts immunity.

    David Jensen, a spokesman for the Ontario health ministry, said there have been 346 adverse events associated with the H1N1 vaccine in the province.
    http://www.healthzone.ca/health/newsfeatures/sw

    Previous post:

    [They're dumping a bunch of VACCINES, supposedly because of expiry dates and refrigeration issues, and, bla, bla, bla. The stuff that they are getting rid of, is the vaccine formula with the adjuvant added]

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  21. My wife and I had the Canadian adjuvenated H1N1 flu shots yesterday. Her arm was a a bit sore for a while. My arm was not. we had no other reactions. We are both 66 years old. We had the regular seasonal flu shot a few weeks earlier. Her arm was sore for a week. Me nothing. She thinks the doctor put the needle in differently the first time. The doctor said the adjuvant is fish oil and vitamin E which probably causes some local irritation and thereby provokes a faster and stronger immune reaction.

    I think people here are over reacting to micro possibilities of possible problems. For example, you get more Hg in a can of tuna than a lifetime of flu shots. How does Janice know that she wouldn't have had a swollen eyelid even if she didn't get the a flu shot? Out of a population of 100,000 in a normal week without flu or flu shots how many will get sick and die? Have allergic reactions? And how many more will there be if they all get the flu? And how many more or less if they all get flu shots? Maybe by worrying about these things, people are trying to create a fantasy of having more control over life than reality allows?

  22. Christopher-Peter

    Influence on the medical profession:
    The medical profession has largely abdicated its responsibility to educate medical students and doctors in the use of prescription drugs. Drug companies now support most continuing medical education, medical conferences and meetings of professional associations. Although they call it education, the billions of dollars they put into it, comes out of their marketing budgets. The industry also provides students, house officers and physicians in practice with meals, trips to exotic locations and many other blandishments. Although medical and industry associations have issued guidelines that would limit these gifts, codes of conduct are entirely voluntary, and full of loopholes.

    Influence on government:
    The pharmaceutical industry has the largest lobby in Washington, DC — there are more pharmaceutical lobbyists there than members of Congress — and it gives copiously, to political campaigns. As a result, the prescription drug legislation and policies that come out of Washington are usually made to order for the industry.
    CMAJ • December 7, 2004; 171 (12). doi:10.1503/cmaj.1041594.
    http://canadianmedicaljournal.ca/cgi/content/fu

    The Central Intelligence Agency owns everyone of any significance in the major media.
    William Colby–1920-1996-Former CIA Director…Suspicious Death.

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  23. You are absolutely correct – in a normal, unvaccinated population many
    events occur. That the same events occur after immunization doesn't
    mean that the vaccine caused them. A nice study has been done on this
    'guilt by association' issue that I'll review here soon.

  24. Christopher-Peter

    Dr. Christopher Shaw is a Neuro-Scientist at the University of British Columbia, (UBC) in Canada, and has published 2 peer reviewed studies which indicate that ALUMINUM and SQUALENE ADJUVANTS in VACCINES are causing neurological DAMAGE and AUTO-IMMUNE disorders,including GULF WAR SYNDROME.

    Is the H1N1 Vaccine Safe?
    Hard Talk on Vaccinations: Featuring Dr. Chris Shaw.
    Recorded in Vancouver on November 7th, 2009 at SPEC Hall.

    Please be advised: The following video lecture presentation has poor audio quality at times, and requires close attention. I found that using headphones helped. It provided for isolation against outside noises and, made for better attenuation.

    Dr. Chris Shaw – Is The H1N1 Vaccine Safe ? (2009)
    http://www.archive.org/details/Dr.ChrisShaw-IsT

    Information provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  25. Christopher-Peter

    For anyone who has chosen to take the shot (swine flu vaccine), if for any reason, God forbid, you have any serious adverse reactions, or any reactions at all, I encourage you to visit the following website and document all, or any of your symptoms, regardless of how insignificant you may think, they seem.

    The website: Canadians for Health Freedom

    H1N1 Vaccine Side Effects – Canadians, Please Report Here!
    http://canadiansforhealthfreedom.wordpress.com/

    Information provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  26. Christopher-Peter

    The Canadian Press-November 19, 2009 – Batch of H1N1 vaccine pulled.
    “Canadians can be assured, that to date, the frequency of serious reactions is less than 1 per 100,000 doses distributed, which is what we've seen with other vaccines,” said Dr. Butler-Jones – CANADA”S CHIEF MEDICAL OFFICER (CMO).

    “It is a serious thing that has the potential to kill” according to a CTV report, but do not worry: “leading experts insist, the benefits of the H1N1 vaccine vastly outweigh the risks.”

    A new development in the H1N1 Vaccine Saga is unfolding in Canada.
    Whereas health officials are pushing for an acceleration of the vaccination program, there is evidence of so-called “unusual adverse reactions” including three recently recorded deaths directly resulting from the vaccine.

    In the meantime, health authorities have called for the withdrawal of 170,000 (higher risk) doses of the vaccine produced by GlaxoSmithKline.
    The initiative, of which the importance is being downplayed, is said to have come from the manufacturer GlaxoSmithKline, which expressed concern on higher than normal adverse reactions to the vaccine.

    The government is involved in a cover-up. The initial headlines stated “more than 100,000 doses”, but then read on, the number is 170,000 doses.

    The CTV report admits that “it is a serious thing, it has the potential to kill”.
    Too Late to Withdraw the 170,000 Defective Doses.

    The question is; whether the doses can be withdrawn or whether they have already been used.

    The first news reports from Manitoba indicate that:
    Of the 63,000 doses shipped [to Manitoba], only 630 remained unused by the four regional health authorities in Manitoba that received them. (Ibid)

    This report would suggest that the risky GSK vaccine doses have already been used.

    A subsequent report confirms that out of the 63,000 doses, 900 unused doses of the H1N1 were withdrawn by health authorities “after health authorities received word other vaccines from the same batch have been causing higher rates of allergic reactions than expected.” (Flu vaccine batch pulled in Manitoba | Manitoba | News | Winnipeg Sun, 20 November 2009).

    It ain't what you don't know that gets you into trouble. It's what you know for sure that just ain't so.
    Mark Twain – 1835-1910

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  27. Christopher-Peter

    PHAC says 24 confirmed cases of anaphylaxis in people who had H1N1 flu shots.
    THE CANADIAN PRESS – November 25, 2009

    TORONTO – There have been 24 confirmed cases of a type of severe allergic reaction called anaphylaxis in Canadians who have received an H1N1 flu shot, including one person who died after getting vaccinated, the head of the PUBLIC HEALTH AGENCY of CANADA (PHAC) said Wednesday.

    Dr. David Butler-Jones said the person who died – identified in the media as a Quebec man in his 80s – met the criteria for having an anaphylactic reaction.

    http://lifestyle.ca.msn.com/health-fitness/news

  28. Christopher-Peter

    DOCS TRY TO SPEED H1N1 VACCINE PRODUCTION – UPI – Sept. 14, 2009
    http://www.upi.com/Health_News/2009/09/14/Docs-

    H1N1's foreign origins and unusual gene mix, frustrate doctors.

    So, a St. Jude research team, in efforts to speed up the process in making a vaccine, “injects chicken eggs with H1N1 and other viruses” in an attempt to create hybrids or mutations.

    H1N1 is a result of the re-assortment of genes from swine, birds and humans, with pigs serving as the “mixing vessel,” scientists said.

    H1N1 virus grows half as quickly as many other flu viruses.

    My question is; if the process of growing the virus is so slow, how was it that they had vaccines “rolling out” shortly after this news report???

    Something stinks in Denmark, and it ain't their rotten vaccinated chicken eggs either!!!

    Information provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  29. Christopher-Peter

    The CDC now reports that nearly 4,000 Americans have been killed by H1N1 swine flu.

    Is it just me, or does Dr. Anne Schuchat of the CDC, appear to be trying to get an OSCAR for her facial expressions, in trying her hardest to show emotions in just the right places, at the right times…she is soooo scripted.
    http://www.youtube.com/watch?v=FHR8pftaFNk

    But more than four times as many people are killed each year by common Non-steroidal anti-inflammatory drugs (NSAID)…painkillers like IBUPROFEN and ASPIRIN.

    American Journal of Medicine. 1998 July 27; 105(1B): 31S-38S.
    Conservative calculations estimate that approximately 107,000 patients are hospitalized annually for non-steroidal anti-inflammatory drug (NSAID)-related gastrointestinal (GI) complications and at least 16,500 NSAID-related deaths occur each year among arthritis patients alone.
    http://www.ncbi.nlm.nih.gov/pubmed/9715832

    Do these 16, 500 deaths from LEGAL DRUG matter, or is hysteria from swine flu the only thing that counts?

    Information compiled and provided by Christopher-Peter: Maingot; without prejudice, malice aforethought, ill will, vexation, or frivolity.

  30. Your comment suggest that Flumist is the sole ingredient in the vial. There surely must be a solvent with preservative and antibiotic included?

    What is Flumist?

  31. OK. 'you get more Hg in a can of tuna than a lifetime of flu shots'.

    Given that this fact turns out to be accurate, the effects of toxins absorbed through the GI tract are quite different in their short and long term effects than those entering the blood stream directly? Those having direct entry to the humeral system (systemic circulation) are not subjected to HCL, digestive enzymes nor
    macrophage activity which probably alters the eventual humeral response.

  32. My two year old son had an asthma attack (first ever) 3 days after receiving his second dose of H1N1 vaccine. Every week or so since, he's gotten hives when exposed to things he was not previously allergic to (peanut butter and cats). Granted those are common allergens but he was not allergic to peanuts previously, and was only mildly allergic to cats – now he seems to suddenly be much more allergic to both. Have you seen any data on asthma and allergy effects due to “hyper-immunity” caused the H1N1 vaccine or adjuvant?

  33. Flumist is infectious, attenuated, vaccine adminstered intranasally.
    The virus is grown in embryonated hen eggs and therefore the vaccine
    contains egg proteins. It does not contain perservative, but it does
    contain the antibiotic gentamicin.

  34. jerrymatiasjr

    my son Michael was born on December, 1983. throughout these years he never had an allergic reactions to the food he eats regularly everyday as well as taking those annual flu vaccines including taking antibiotics whenever he needs it. however – when he got injected with the H1N1 swine flu vaccine last December, 2009, a side effect occured more than (2) weeks after getting the injection. Michael began to experienced itchy skin on his arms, legs and feet. this is the first time that something serious like this skin problems happened to him and it all started more than (2) weeks after having that H1Ni vaccine flu shot. Michael is now suffering from open wounds due to scratching the skin rashes that flared up. on January 8, 2009 we went to see his family doctor. he was prescribed 200 gm 2% Clindamycin in Ectosone 0.1% cream to stop the itching and help the wounds to heal. the itching stop for awhile – but started again Wednesday, February 17, 2010. we decided to see another doctor for a secong opinion and this time on Thursday, Feb. 18, 2010 the same medicine was prescribed only stronger in tablet form (novo-clindamycin 300 mg). it help a little bit but on March 4, 2010 the same itching occured again. MIchael can help scracthing the old wounds and now he has opened wounds that are infected. the Clindamycin that was previously prescribed by (2) different doctors is not working and so I was force to get a third opinion. this time when went to another family doctor last Monday, April 5, 2010. he was precribed Apo-Cephalex 250 mg tablet and 30 gm Fucidin cream to kill the bacteric to help heal the wounds. Michael is now waiting to see an specialist (Dermatologist) to hopefully find and fix the problem. the reason – I am sharing you this problem – is to try to find a way to help Michael as urgently as possible. If you can help – please let me know via e-mail so I can share it with the proper channels. Michael needs medical help and I am doing the best I can to assist him with your guidance. all I know that what is happening to Michael started (2) weeks after getting the H1N1 flu shot. Thank you.

  35. Christopher-Peter

    Nursing Home Test; 'Didn't find' proof immunization stops virus.
    Tom Blackwell, National Post – March 11, 2010

    A new Canadian-led study has added to a simmering scientific dispute over flu-shot campaigns, concluding that immunizing nursing-home workers does nothing to cut the number of confirmed influenza cases among the homes' elderly residents.

    Coming at the end of the largest flu-vaccination campaign in Canadian history, the review of previous studies calls for stepped-up research into alternative, lower-tech ways to combat the virus, such as improved hand washing.

    In media interviews last year, Dr. Jefferson was quoted as saying he “can't see any reason” for vaccinating anyone against flu — arguing the shots did nothing to save lives — and that most influenza-vaccine studies are “rubbish.”

    Search this title for full story: Flu shots for nursing home workers futile: study

    Cochrane Database Syst Rev. 2010 Feb 17;2:CD005187.
    Department of Medicine, University of Calgary, UCMC, #1707-1632 14th Avenue, Calgary, Alberta, Canada, T2M 1N7.

    Some HCWs remain unvaccinated because they do not perceive risk, doubt vaccine efficacy and are concerned about side effects.

    We conclude there is no evidence that vaccinating Health Care Workers (HCWs) prevents influenza in elderly residents in Long Term Care Facilities (LTCFs).

    Search this title for excerpt of study: Influenza vaccination for healthcare workers who work with the elderly.

  36. Christopher-Peter

    U.S.News & World Report – April 6, 2010

    The traditional seasonal flu vaccine may have increased the risk of infection with pandemic H1N1 swine flu, according to the results of four new studies by Canadian researchers.

    In one study, the researchers used an ongoing sentinel monitoring system to assess the frequency of prior vaccination with the seasonal flu vaccine in people diagnosed with H1N1 swine flu in 2009 compared to people without swine flu. The researchers found that seasonal flu vaccination was associated with a 68 percent increased risk of getting swine flu.

    Search this title for full story: Did 'Regular' Flu Shot Up Risks for H1N1 Flu?

    Here is the link:
    http://www.usnews.com/health/managing-your-heal

  37. Christopher-Peter

    Nursing Home Test; 'Didn't find' proof immunization stops virus.
    Tom Blackwell, National Post – March 11, 2010

    A new Canadian-led study has added to a simmering scientific dispute over flu-shot campaigns, concluding that immunizing nursing-home workers does nothing to cut the number of confirmed influenza cases among the homes' elderly residents.

    Coming at the end of the largest flu-vaccination campaign in Canadian history, the review of previous studies calls for stepped-up research into alternative, lower-tech ways to combat the virus, such as improved hand washing.

    In media interviews last year, Dr. Jefferson was quoted as saying he “can't see any reason” for vaccinating anyone against flu — arguing the shots did nothing to save lives — and that most influenza-vaccine studies are “rubbish.”

    Search this title for full story: Flu shots for nursing home workers futile: study

    Cochrane Database Syst Rev. 2010 Feb 17;2:CD005187.
    Department of Medicine, University of Calgary, UCMC, #1707-1632 14th Avenue, Calgary, Alberta, Canada, T2M 1N7.

    Some HCWs remain unvaccinated because they do not perceive risk, doubt vaccine efficacy and are concerned about side effects.

    We conclude there is no evidence that vaccinating Health Care Workers (HCWs) prevents influenza in elderly residents in Long Term Care Facilities (LTCFs).

    Search this title for excerpt of study: Influenza vaccination for healthcare workers who work with the elderly.

  38. Christopher-Peter

    U.S.News & World Report – April 6, 2010

    The traditional seasonal flu vaccine may have increased the risk of infection with pandemic H1N1 swine flu, according to the results of four new studies by Canadian researchers.

    In one study, the researchers used an ongoing sentinel monitoring system to assess the frequency of prior vaccination with the seasonal flu vaccine in people diagnosed with H1N1 swine flu in 2009 compared to people without swine flu. The researchers found that seasonal flu vaccination was associated with a 68 percent increased risk of getting swine flu.

    Search this title for full story: Did 'Regular' Flu Shot Up Risks for H1N1 Flu?

    Here is the link:
    http://www.usnews.com/health/managing-your-heal

  39. I was wondering too if the swine flu shot would have triggered an autoimmune disorder also in my 15 year old daughter?

  40. The graph is taken from the paper, which is referenced at the bottom
    of the post. You could ask the authors what they used.

  41. “MF59 has been used for 12 years in seasonal influenza vaccines in Europe”
    Yes, but for individuals 65 years of age and older.

  42. Is the same adjuvant can be used in multiple vaccines? How can you choose the right adjuvan for a vaccine is it screening or are there clear scientific guidlines?

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