Virology

A new drug for influenza

A new drug has been approved by the US Food and Drug Administration for the treatment of influenza. Called Xofluza (baloxavir carboxyl), it is the first influenza drug approved in 20 years with a new mechanism of action. How does Xofluza work? Influenza virus particles contain (-) RNAs, which means ...

TWiV 516: HUSH little virus, don’t you transcribe

Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&amp;lt;span data-mce-type="bookmark" style="display: inline-block; ...

My letter to organizer of 4th Columbia Psychosomatics Conference

Yesterday I sent an email to Dr. Landa who had previously written to David Tuller about the 4th Columbia Psychosomatics Conference (link to David's post). Like David, I was unhappy about Dr. Landa's note so I decided to write her and see if she might respond better to a Columbia ...

A cell RNA that regulates innate immunity

All immune responses, from intrinsic to adaptive, need to be regulated - if left on indefinitely they will damage the host. The innate immune response is no exception, and a cellular RNA has been identified that binds to a sensor of viral RNA and regulates the production of interferon (IFN). ...

ME/CFS is not a psychosomatic illness

W. Ian Lipkin, Director of the Center for Infection and Immunity and the Center for Solutions for ME/CFS at Columbia University, has written the following letter several days before the Fourth Annual Conference on Psychosomatics at Columbia University this weekend. The original letter can be found at this link. 18 October 2018 ...
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