by Gertrud U. Rey There are currently 315 therapeutic drugs and 210 vaccine candidates in development to treat or prevent SARS-CoV-2 infection. Many of these vaccines are designed to be administered by injection into the muscle.  Intramuscular injection of a vaccine antigen typically induces a systemic (serum) immune response that involves the ...

Daniel Griffin provides a clinical report on COVID-19, then we discuss CDC softening testing guidelines, Moderna vaccine phase I results in older people, Abbott's $5 rapid antigen test, and reinfection with a distinct SARS-CoV-2 isolate, followed by listener email. Click arrow to playDownload TWiV 658 (85 MB .mp3, 141 min)Subscribe (free): iTunes, Google ...

Not only the popular press but even some of my distinguished science colleagues are claiming that the recent report of reinfection of a COVID-19 patient is the end of the world. Nothing could be farther from the truth. First, the facts. The patient is a healthy Hong Kong male who ...

Immunologist Shane Crotty joins TWiV to discuss the antibody and T cell responses to infection with SARS-CoV-2, followed by answers to listener questions. Click arrow to playDownload TWiV 657 (80 MB .mp3, 133 min)Subscribe (free): iTunes, Google Podcasts, RSS, emailBecome a patron of TWiV! Show notes at microbe.tv/twiv

Sociomedical scientist Robert Fullilove joins TWiV to discuss disparities in minority health; FDA announces an EUA on Yale's SalivaDirect, protection of the upper and respiratory tract of mice after intranasal inoculation with an adenovirus-vectored SARS-CoV-2 spike gene, and listener questions. Click arrow to playDownload TWiV 655 (88 MB .mp3, 147 min)Subscribe ...