Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Click arrow to playDownload TWiV 677 (97 MB .mp3, ...

In infectious disease world, the term €œcorrelate of protection€ refers to something that can be measured - antibodies or T cells - which indicates that a person is protected against infection or disease. The correlates of protection for SARS-CoV-2 infection of humans are not yet known - after all it ...

In this episode we explain how regions of the human genome associated with severe COVID-19 are identified, the finding that one of these regions was inherited from Neanderthals, and prolonged SARS-CoV-2 reproduction in an immunocompromised patient. Click arrow to playDownload TWiV 676 (72 MB .mp3, 120 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! ...

Daniel Griffin provides a clinical report on COVID-19, then we discuss Bill Foege's letter to CDC director Robert Redfield, the false promise of herd immunity for COVID-19, secret blueprints for SARS-CoV-2 vaccine trials released, and neuropilin-1 as a possible entry protein for the virus. Click arrow to playDownload TWiV 675 (105 ...

Although we are less than a year into the SARS-CoV-2 pandemic, it appears that the antibodies induced by infection are often of poor quality, and B cell memory seems limited. An explanation for this outcome might be a consequence of the loss of germinal centers in COVID-19 patients. Examination of ...