Viral replication frequently leads to the accumulation of intracellular masses of virions or unassembled viral components in the cytoplasm or nucleus of the cell. These inclusion bodies often bear the name of the individual who discovered them - such as Guarnieri bodies in the cytoplasm of poxvirus infected cells, intranuclear ...

I joined host Dr. Marc Pelletier on the TWiT podcast 'Futures in Biotech' to interview influenza virologist Dr. Peter Palese, professor and chair of microbiology at the Mount Sinai School of Medicine in New York. We talk about influenza and why Dr. Palese revived a virus that killed 50 million people. Download Futures ...

Last week on TWiV #26 Rich Condit and I were reminiscing about the possibility that we had received the virus SV40 along with our polio immunizations. That discussion prompted me to examine my immunization record for poliovaccine that my Mother had given to me in the early 1990s. She was ...

On episode #26 of the podcast "This Week in Virology", Vincent, Alan, and Rich Condit converse about induction of polyomavirus replication in multiple sclerosis patients treated with the MS drug Tysabri, the extent of human polyomavirus infection, selection of influenza vaccines for the 2009-10 season, cowpox virus transmission from animals ...

While immunosuppressive therapy can ameliorate a variety of diseases, one unfortunate side effect of the treatment is that it may lead to pathogenic infections by viruses which would otherwise be benign. An example is the brain infection PML which occurs when immunosuppression leads to replication of the polyomavirus JC. How ...