by Gertrud U. Rey Most people associate viruses with illness and suffering. After all, the word "virus" is derived from the Latin word for "poison." However, considering that the vast majority of viruses cause no illness and are actually beneficial to humans and the planet as a whole, this sentiment ...

Another excellent example of gain of function research is modification of a viral vector to make it more useful for human gene therapy. Adenovirus associated virus (AAV) is the most commonly used vector for a variety of gene therapy applications, including gene replacement and gene editing. These small viruses, which ...

Various SARS-CoV-2 like viruses have been isolated from bats in China, Thailand, and Japan, but none have a spike protein that can bind ACE2 and allow entry into human cells. Sampling of bats in Laos has now revealed the presence of such viruses. The genome of a virus called RaTG13, ...

The recent release of grant materials from EcoHealth Alliance pertaining to their research with the Wuhan Institute of Virology has been used to demonstrate that gain of function research was funded by the NIH. This conclusion is correct, although not all the experiments done would fall into this category. One ...

The term 'gain of function' is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an ...