Virology
SARS-CoV-2 related viruses from bats in Laos
By Vincent Racaniello
Various SARS-CoV-2 like viruses have been isolated from bats in China, Thailand, and Japan, but none have a spike protein that can bind ACE2 and allow entry into human cells. Sampling of bats in Laos has now revealed the presence of such viruses. The genome of a virus called RaTG13, ...
A zero time point is essential
By Vincent Racaniello
The recent release of grant materials from EcoHealth Alliance pertaining to their research with the Wuhan Institute of Virology has been used to demonstrate that gain of function research was funded by the NIH. This conclusion is correct, although not all the experiments done would fall into this category. One ...
Gain of function research explained
By Vincent Racaniello
The term 'gain of function' is perhaps one of the most misunderstood in the scientific lexicon. I would like to explain what the phrase means from the perspective of a scientist who has done gain of function research for the past 40 years. Gain of function (GoF) research gives an ...
Innately Immune
By Gertrud U. Rey
by Gertrud U. Rey It is still not entirely clear why children are less susceptible to severe COVID-19. Early hypotheses included the possibility that children may have a stronger innate immune response, which is the response that occurs upon an initial encounter with a pathogen. Results from a recent study ...
More coronaviruses in rodents
By Vincent Racaniello
This week President Biden received the report he commissioned on the origin of SARS-CoV-2. As I predicted three months ago, nothing was learned, because to find the origin of the virus it is necessary to conduct extensive wildlife surveys. Consequently this week I would rather write about a new study ...