Virology
TWiV 237: Paleovirology with Michael Emerman
By Vincent Racaniello
Episode #237 of the science show This Week in Virology was recorded at the Fred Hutchinson Cancer Research Center in Seattle, WA, where Vincent and Rich met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis. You can find TWiV #237 at ...
The wall of polio
By Vincent Racaniello
The Polio Wall of Fame (pictured) is a set of fifteen sculptured busts of 17 individuals who made important contributions to understanding and preventing poliomyelitis. The busts are mounted on an exterior wall of Founder's Hall at the Roosevelt Warm Springs Institute for Rehabilitation in Warm Springs, Georgia, USA. In my laboratory ...
A single amino acid change switches avian influenza H5N1 and H7N9 viruses to human receptors
By Vincent Racaniello
Two back-to-back papers were published last week that provide a detailed analysis of what it would take for avian influenza H5N1 and H7N9 viruses to switch to human receptors. Influenza virus initiates infection by attaching to the cell surface, a process mediated by binding of the viral hemagglutinin protein (HA) ...
TWiV 236: Flu gets the VIP treatment
By Vincent Racaniello
On epside #236 of the science show This Week in Virology, Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection. You can find TWiV #236 at www.microbe.tv/twiv.
Treating hepatitis C by blocking a cellular microRNA
By Vincent Racaniello
Miravirsen is a drug that binds to and blocks the function of a cellular microRNA called miR-122 that is required for the replication of hepatitis C virus (HCV). Treatment of chimpanzees chronically infected with HCV with this drug leads to suppression of viral replication. The results of a phase 2b ...