Virology
A transmissible cancer of soft-shell clams
By Vincent Racaniello
A leukemia-like cancer is killing soft-shell clams along the east coast of North America. The cancer is transmitted between animals in the ocean, and appears to have originated in a single clam as recently as 40 years ago. Hemic neoplasm is a disease of marine bivalves that is characterized by proliferation of ...
TWiV 331: Why is this outbreak different from all other outbreaks?
By Vincent Racaniello
On episode #331 of the science show This Week in Virology, the TWiV team discusses the possible association of the respiratory pathogen enterovirus D68 with neurological disease. You can find TWiV #331 at www.microbe.tv/twiv.
HeLa RNA is everywhere
By Vincent Racaniello
The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon was found to contaminate other cell lines. Now HeLa RNA has made its way into human sequence ...
TWiV 330: A swinging gate
By Vincent Racaniello
On episode #330 of the science show This Week in Virology, the TWiVers explain how a protein platform assists the hepatitis C virus RNA polymerase to begin the task of making viral genomes. You can find TWiV #330 at www.microbe.tv/twiv.
A protein platform for priming
By Vincent Racaniello
The enzymes that make copies of the DNA or RNA genomes of viruses - nucleic acid polymerases - can be placed into two broad categories depending on whether or not they require a primer, a short piece of DNA or RNA, to get going. The structure of the primer-independent RNA polymerase ...