Virology
An open letter to Psychological Medicine about “recovery” and the PACE trial
By Vincent Racaniello
Sir Robin Murray and Dr. Kenneth Kendler Psychological Medicine Cambridge University Press University Printing House Shaftesbury Road Cambridge CB2 8BS UK Dear Sir Robin Murray and Dr. Kendler: In 2013, Psychological Medicine published an article called Recovery from chronic fatigue syndrome after treatments given in the PACE trial.[1] In the paper, White et al. reported that graded ...
TWiV 432: Conjunction junction, what’s your function?
By Vincent Racaniello
The TWiVites discuss Zika virus seroprevalence in wild monkeys, Zika virus mRNA vaccines, and a gamete fusion protein inherited from viruses. You can find TWiV #432 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 432 (65 MB .mp3, 108 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Did viruses enable sex?
By Vincent Racaniello
Dengue virus E glycoproteins (monomer at top) lie flat on the virus particle as dimers (middle). At endosomal low pH, three monomers reorient to place the fusion peptide (orange) into the cell membrane. Image credit. A key step in sexual reproduction is the fusion of haploid cells to form a diploid zygote, yet ...
TWiV 431: Niemann-Pick of the weak
By Vincent Racaniello
The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak. You can find TWiV #431 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 431 (71 MB .mp3, 118 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
A virus that controls reproduction
By Vincent Racaniello
The obligate intracellular bacteria Wolbachia (pictured), which infects 40% of arthropods, can manipulate its host to ensure its maintenance in the population. An example is cytoplasmic incompatibility, which occurs when infected males mate with uninfected females, and causes embryonic lethality (mating with an infected female produces viable offspring). Two Wolbachia genes ...
