Thirty-five years ago this month, in September 1982, I arrived at Columbia University College of Physicians & Surgeons to open my virology laboratory. I brought with me an infectious DNA copy of the poliovirus RNA genome, the first of its kind, and a lot of enthusiasm. Over the years we ...

Brianne returns to the TWiV Gang to discuss the distribution of proteins on the influenza viral genome, and the evolution of myxoma virus that was released in Australia to control the rabbit population. Click arrow to play Download TWiV 457 (74 MB .mp3, 123 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at ...

Plasmids have been discovered that can move from cell to cell within membrane vesicles in a species of Archaea (link to paper). They provide clues about the origin of virus particles. Electron microscope analysis of the culture medium from Halobrum lacusprofundi R1S1, an Archaeal strain from Antarctica, revealed spherical particles ...

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.   Click arrow to play Download TWiV 456 (75 MB .mp3, 124 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv.

Not long after their discovery, viruses that infect bacteria - bacteriophages - were considered as therapeutic agents for treating infections. Despite many years of research on so-called phage therapy, clinical trials have produced conflicting results. They might be explained in part by the results of a new study which show that ...