The influenza virus vaccine is frequently updated to ensure that it protects against infection with circulating virus strains. In some years the vaccine matches the circulating strains, but in others, there is a mismatch. The result is that the vaccine is less effective at protecting from infection. During the 2014-15 ...

The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science. <span data-mce-type="bookmark" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt; Click arrow to play Download TWiV 469 (66 MB .mp3, 108 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! ...

Cindy, Steph, and Vincent reveal that lymphocyte trafficking through lymph nodes and lymph is circadian - it is dependent on the time of day. <span data-mce-type="bookmark" class="mce_SELRES_start"></span> Click arrow to play Download Immune 2 (53 MB .mp3, 87 min) Subscribe (free): iTunes, RSS, email Become a patron of Immune! Show notes at microbe.tv/immune

Amy Rosenfeld joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures. <span data-mce-type="bookmark" class="mce_SELRES_start"></span> Click arrow to play Download TWiV 468 (66 MB .mp3, 107 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

When you are infected with a microbe, pieces of the pathogen are picked up by sentinel dendritic cells and brought to local lymph nodes. There the sentinels present their gifts to lymphocytes - B (pictured; image credit) and T cells - who then decide if they are foreign, in which ...