Virology

Ebolavirus infections but no outbreak

Ebolavirus infections are feared because of the high fatality rate observed during outbreaks, from 25-90%. But there is evidence that far less serious Ebolavirus infections may occur in the absence of outbreaks. The latest study was conducted in late 2007 and comprised 3415 subjects living in 14 rural villages in ...

TWiV 481: And biles to go before I delete

The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&amp;lt;span data-mce-type="bookmark" style="display: ...

Defective viral genomes and severe influenza

The virulence of a virus - its capacity to cause disease - is determined by both viral and host factors. Even among healthy individuals, infection with a particular virus may have different outcomes ranging from benign to lethal. The study of influenza viruses that cause mild or fatal outcomes reveals ...

TWiV 480: The PFU in your achoo

Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. <span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"></span>&lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; line-height: 0;" class="mce_SELRES_start"&gt;&lt;/span&gt;&amp;lt;span data-mce-type="bookmark" style="display: inline-block; width: 0px; overflow: hidden; ...

A breath of fresh influenza virus

Influenza virus may be transmitted among humans in three ways: by direct contact with infected individuals; by contact with contaminated objects (called fomites, such as toys, doorknobs); and by inhalation of virus-laden aerosols. A recent study suggests that normal tidal breathing plays a substantial role in aerosol transmission. Volunteers in a ...
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