The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer’s Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles.  Click arrow to play Download TWiV 519 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Alois Alzheimer was the first to propose that an infection might play a role in the disease named after him. Herpes simplex virus type 1 (HSV-1) has been most frequently linked to Alzheimer€™s Disease (AD), and a clinical trial is in progress to determine if antivirals ameliorate its development. What is the evidence that HSV-1 …
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick Buchkovich and Leslie Parent about their careers and their work on human cytomegalovirus and retroviruses. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 518 (53 MB .mp3, 86 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become …
By Gertrud U. Rey Post-transcriptional gene silencing (PTGS) is an RNA regulation pathway in eukaryotes that depends on the presence of double stranded RNA (dsRNA) in the cytoplasm of cells. As stated by Nels Elde in TWiEVO 8, dsRNA in the cytoplasm has an effect synonymous to “blood in the water” for the innate immune …
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC.  Click arrow to play Download TWiV 517 (48 MB .mp3, 79 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! …
A new drug has been approved by the US Food and Drug Administration for the treatment of influenza. Called Xofluza (baloxavir carboxyl), it is the first influenza drug approved in 20 years with a new mechanism of action. How does Xofluza work? Influenza virus particles contain (-) RNAs, which means that they cannot be translated …
