Vincent travels to the University at Albany to speak with Cara, Rachel, and Alex about their careers and their work on stress granules, epitranscriptomics, and arboviruses. Click arrow to play Download TWiV 547 (58 MB .mp3, 96 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
by Gertrud U. Rey Dengue fever, caused by dengue virus (DENV), is of substantial public health significance in the tropics, where the virus is spread by Aedes mosquitoes. Last week the FDA announced its approval of a first vaccine for the prevention of dengue disease in endemic areas.
Hepatitis D virus is a unique human pathogen. With a circular, negative stranded RNA genome of ~1700 nucleotides, it is the smallest known human virus. Formation of the HDV particle depends on co-infection of cells with a helper virus, hepatitis B virus. Once thought to be specific for humans, related viruses have now been identified …
Viral infection of vertebrates leads to the production of antibodies, and some of these can block virus infection by a process that is called neutralization. Antibodies can neutralize viral infectivity in a number of ways: they may impair virus entry into cells, and even cause degradation of the capsid in the cytoplasm. A newly discovered …
Complementing neutralization of viruses by antibodies Read More »
The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Click arrow to play Download TWiV 544 (65 MB .mp3, 108 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
When we are born, our blood contains antibodies that we have inherited from our mothers. They are transferred across the placenta and provide protection from infection until IgG production begins around 15 weeks after birth. Can we exploit such antibody transfer by vaccinating pregnant mothers to protect newborns against infectious diseases that occur early after …
