Would influenza virus be the same pathogen if it could not undergo reassortment of its segmented RNA genome? This is the question being asked in the wake of the development of a method to prevent the free assortment of influenza viral RNAs. The process of influenza virus replication includes the incorporation of eight viral RNAs …
Hosts: Vincent Racaniello and Dick Despommier On episode 49 of the podcast ‘This Week in Virology”, Vincent and Dick continue Virology 101 with a discussion of the seven different types of viral genomes, and how to use the pathway to mRNA to understand viral replication. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV049.mp3″] Click the arrow above to play, or right-click …
In a recent study of influenza virus reassortment in ferrets, the authors used polymerase chain reaction (PCR) to search for viruses with RNA segments from the 2009 pandemic H1N1 strain and seasonal H1N1 and H3N2 strains. I thought you might like to see how I did a similar experiment in 1979 – a very different …
An Australian group has reported results of a clinical trial to determine the safety and immunogenicity of a 2009 pandemic H1N1 influenza virus vaccine. Twenty-one days after the first of two scheduled doses, the vaccine proved to be immunogenic in adults. This is good news, as many had believed that two doses of the vaccine …
Single dose of 2009 H1N1 vaccine immunogenic in adults Read More »
When more than one influenza A virus subtype is circulating in humans, as has been the case since 1977, there are several possible outcomes. The viruses might co-circulate, one virus might out-compete another, or co-infection of cells with two viruses can lead to the production of genetically distinct viruses by the process of reassortment of …
Pandemic H1N1 influenza virus outcompetes seasonal strains in ferrets Read More »
Of the many questions that I receive about influenza, one of the most common is “when will swine flu return to the US?”. In other words, when will the 2009 pandemic H1N1 strain, first recognized in humans in April 2009, emerge for the 2009-2010 influenza season? “Return” is probably not the correct word to use, …
