The recent discovery of contaminating porcine circovirus 1 DNA in Rotarix underscores the power of deep sequencing to ensure the purity of viral vaccines. The price of deep sequencing is now low enough that it is possible to use this technology to examine not just viral vaccines, but any biological product produced in mammalian cells …
Hosts: Vincent Racaniello, Alan Dove, and Matthew Frieman Vincent, Alan, and Matt review contamination of Rotarix with circovirus DNA, antigenic similarity between 1918 and 2009 H1N1 influenza, a collection of rabies reports, and chicken pox mistaken for smallpox in Uganda. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive …
The US Food and Drug Administration has recommended that administration of the Rotarix vaccine, which protects against rotavirus infection, be suspended. This action comes after an independent research group found that the vaccine contains DNA of porcine circovirus type 1. Rotaviruses are the single leading cause of diarrhea in infants and young children. Each year …
Hosts: Vincent Racaniello and Adolfo Garcia-Sastre Vincent speaks with Adolfo Garcia-Sastre talk about the origin, pathogenesis, and prevention of the 2009 pandemic influenza H1N1 virus. This episode is sponsored by Data Robotics Inc. Use the promotion code VINCENT to receive $50 off a Drobo or $100 off a Drobo S. Win a free Drobo S! …
TWiV #74: Influenza with Professor Adolfo Garcia-Sastre Read More »
The World Health Organization and the US Food & Drug Administration have decided on the composition of the influenza virus vaccine that will be used during the 2010-2011 season in the northern hemisphere. The trivalent preparation will contain the following influenza virus strains: A/California/7/2009 (H1N1); A/Perth/16/2009 (H3N2); and B/Brisbane/60/2008. The same trivalent vaccine is also being used to …
Trivalent influenza vaccine for the 2010-2011 season Read More »
No matter what advanced method is used to develop and produce vaccines, their efficacy is limited by old technology – the refrigerator. All viral vaccines must either be stored frozen, or kept at low temperatures. If they are not properly stored, they lose potency and do not confer protection against infection. The decay of vaccine …
