tumor suppressor

p53 throws a wrench in the CRISPR/Cas9 gears

Of all the potential uses for genome editing via CRISPR/Cas9, perhaps the most exciting involves introducing therapeutic changes into human pluripotent stem cells (hPSCs) which can then be differentiated into many different cell types. A serious obstacle to such engineering is the finding that the tumor suppressor p53 inhibits CRISPR/Cas9 editing in hPSCs.

TWiV 314: Einstein goes viral

On episode #314 of the science show This Week in Virology, Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells. You can find TWiV #314 at www.microbe.tv/twiv.

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