by Gertrud U. Rey There are several highly effective vaccines that block infection by human papillomaviruses (HPVs) and thereby prevent the cervical, anogenital, and head and neck cancers caused by these viruses. However, none of these vaccines are effective for the treatment of established HPV-induced tumors. The success of the COVID-19 messenger RNA (mRNA) vaccines …
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Click arrow to play Download TWiV 530 (65 MB .mp3, 107 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
The diversity of cellular RNA structure and function has progressed from the early days of molecular biology, when we thought only about mRNA, tRNA and ribosomal RNAs. Then RNA splicing was discovered along with the many small nuclear RNAs that mediate that process. Next came small interfering RNAs and microRNAs and long noncoding RNAs, master …
Oncogenes of DNA tumor viruses encode proteins that cause cells to divide incessantly, eventually leading to formation of a tumor. These oncoproteins have now been found to antagonize the innate immune response of the cell (link to paper). Most cells encountered by viruses are not dividing, and hence do not efficiently support viral DNA synthesis. The …
A new function for oncoproteins of DNA tumor viruses Read More »
Guest host Lynda Coughlan reviews how oncolytic viruses, which specifically kill tumor cells, are designed and how they work.
Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy €“ using viruses to treat cancers. Recorded before an audience at ASV 2016 at Virginia Tech in Blacksburg, Virginia. You can find TWiV #395 at microbe.tv/twiv, or listen/view below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV395.mp3″] Click arrow to play Download TWiV 395 (44 MB .mp3, 60 min) Subscribe (free): iTunes, RSS, email, Google Play Music Become …
