by Gertrud U. Rey During the first few months of life, residual maternal antibodies that crossed the placenta during gestation and antibodies from breast milk protect infants from infection with various microbes. This type of immune protection is known as “passive immunity,” and differs from “active immunity,” which develops in an individual following vaccination or …
This episode of TWiV is focused on COVID-19 vaccines and antibodies: who should get boosters, whether a variant matched mRNA vaccine is superior to a historical vaccine, and how the interval between vaccination and infection influences the quality of the antibody response.
Intranasal administration with a single dose of a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine induces potent immune responses.
TWiV reviews an experimental, intranasally administered SARS-CoV-2 vaccine that utilizes adenovirus vectors to deliver three viral proteins and induces immunity to ancestral and variant isolates. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler Click arrow to playDownload TWiV 867 (128 MB .mp3, 107 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
A heterologous vaccine regimen consisting of a first dose of the AstraZeneca vaccine and a second dose of the Pfizer vaccine induces a stronger immune response than a regimen consisting of two doses of the AstraZeneca vaccine.
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Click arrow to playDownload TWiV 684 (110 MB .mp3, 184 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv
