Most of the 172 SARS-CoV-2 vaccines in development will be administered by intramuscular injection, a traditional route for many effective vaccines. In my opinion the use of needles for immunization will one day be replaced by microneedle patches, which can not only be self-administered but have a variety of other advantages compared with injection. A …
Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Click arrow to playDownload TWiV 631 (72 MB .mp3, 119 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Jessie, Allie and Tyler join Nels and Vincent to describe their work on deep mutational scanning of the SARS-CoV-2 receptor binding domain. Click arrow to playDownload TWiEVO 57 (50 MB .mp3, 84 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiEVO Show notes at microbe.tv/twievo
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email. Click arrow to playDownload TWiV 629 (95 MB .mp3, 158 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes …
Despite recent proclamations to the contrary by WHO, there is good evidence that individuals who are asymptomatically infected with SARS-CoV-2 can efficiently spread infection to others. The levels of virus and the immune response in asymptomatically infected individuals has not been well studied to understand the infection events taking place. A recent small study provides …
Virus and antibodies during asymptomatic SARS-CoV-2 infections Read More »
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Click arrow to playDownload TWiV 626 (98 MB .mp3, 163 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
