SARS-CoV-2

TWiV 831: COVID-19 clinical update #89 with Dr. Daniel Griffin

This Week in Virology / By Vincent Racaniello

In COVID-19 clinical update #89, Dr. Griffin reviews upcoming meeting on FDA emergency use authorization for molnupiravir, 25% of US cases in children, reinfection associates with presence of antibodies, national surveillance for acute flaccid myelitis in the US, and monoclonal antibody treatment of infection in vaccinated, high-risk individuals. Click arrow to playDownload TWiV 831 (20 MB .mp3, …

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TWiV 830: A culture of resistance

This Week in Virology / By Vincent Racaniello

TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitrowould not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the …

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TWiV 829: Antiviral and cytotoxically empowered for COVID-19

This Week in Virology / By Vincent Racaniello

A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19. Click arrow to playDownload TWiV 829 (67 MB .mp3, 112 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv

TWiV 828: COVID-19 clinical update #88 with Dr. Daniel Griffin

This Week in Virology / By Vincent Racaniello

In COVID-19 clinical update #88, Dr. Griffin covers vaccine protection among US veterans, absence of long COVID in vaccinated who are infected, single dose of REGEN-COV monoclonal antibody cocktail provides long term protection, and Pfizer protease inhibitor Paxlovid is 89% effective in preventing hospitalization or death. Show notes at microbe.tv/twiv

Pills for COVID-19

4 Comments / Basic virology, Information / By Vincent Racaniello

Multiple vaccines have been developed that have made substantial contributions to controlling the COVID-19 pandemic, but where are the antivirals? Only repurposed drugs have been used and not with much success. That situation seems about to change with the authorization of drugs that target the RNA polymerase (Molnupiravir) and a viral protease (Paxlovid). Molnupiravir is …

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Spikevax Induces Durable Protection from the Delta Variant in Rhesus Macaques

2 Comments / Basic virology, Gertrud Rey / By Gertrud U. Rey

Rhesus macaques that are vaccinated against SARS-CoV-2 are protected from severe disease and probably transmit very little virus when infected with SARS-CoV-2 one year later.

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