retrovirus

Ila Singh finds no XMRV in patients with chronic fatigue syndrome

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Since the first association of the retrovirus XMRV with chronic fatigue syndrome in 2009 in the US, subsequent studies have failed to detect evidence of infection in patients from the US, Europe, and China. These studies were potentially compromised by a number of factors, such as differences in patient characterization, geographic locations, clinical samples used, …

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Retroviruses and amyotrophic lateral sclerosis

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Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease or Lou Gehrig’s disease, is a fatal disorder of unknown etiology. The disease involves degeneration of motor neurons, leading to paralysis, respiratory failure, and death within five years. A viral etiology for ALS has been suggested but never proven. Retroviruses have been considered because they …

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TWiV 127: Viruses are no joke

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Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV127.mp3″] Click the arrow above to play, or right-click to download TWiV #127 (62 MB .mp3, …

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TWiV 125 – TWiV infects FiB

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Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Marc Pelletier This Week in Virology and Futures in Biotech join together in a science mashup to talk about a virophage at the origin of DNA transposons, and unintended spread of a recombinant retrovirus. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV125.mp3″] Click the arrow above to play, or right-click to download TWiV #125 …

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TWiV 123: Contaminated prostates, absolute truth, and bleached worms

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Hosts: Vincent Racaniello, Alan Dove, and Rich Condit On episode #123 of the podcast This Week in Virology, Vincent, Alan, and Rich talk about XMRV integration sites in prostate tumor DNA, the decline effect and scientific method, and the first virus of Caenorhabditis nematodes. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV123.mp3″] Click the arrow above to play, or right-click to download TWiV #123 …

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Authenticity of XMRV integration sites

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Integration of retroviral DNA into the cellular genome is essential for the production of new infectious particles. A strong argument that the novel human retrovirus XMRV is not a laboratory contaminant is the finding that viral DNA is integrated in chromosomal DNA of prostate tumors. Nucleotide sequence analyses of 14 integration sites in prostate tumor DNAs …

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