Virology lecture #6: RNA-directed RNA synthesis
Download: .wmv (324 MB) | .mp4 (76 MB) Visit the virology W3310 home page for a complete list of course resources.
replication
TWiV 60: Making viral RNA
Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dick continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV060.mp3″] Click the arrow above to play, or right-click to download TWiV #60 (51 MB .mp3, 71 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by …
Virology lectures
Each year I teach basic virology to medical, dental, and nursing students here at Columbia University Medical Center. You can find all the lecture videos, slides, and readings here at virology blog: virology.ws/course.
A better influenza virus animation
Earlier this year an influenza virus animation spread on YouTube just after the emergence of swine-origin influenza H1N1. I invited readers to criticise the animation which contained several errors. A much better depiction of influenza virus animation has been created by XVIVO. It’s not only more beautifully rendered, but is scientifically much more accurate. A …
The error-prone ways of RNA synthesis
Now that we have examined influenza viral RNA synthesis, it’s a good time to step back and look at a very important property of this step in viral replication. All nucleic acid polymerases insert incorrect nucleotides during chain elongation. This misincorporation is one of the major sources of diversity that allows viral evolution to take …
Influenza virus attachment to cells
We’ve briefly considered the structure of influenza virions and how the viral RNAs can encode one or more proteins. Now we’ll consider how influenza viruses multiply. Viruses are obligate intracellular parasites: they cannot reproduce outside of a cell. The production of new infectious particles must take place within a cell. Upon entering cells, viruses parasitize …