A coronavirus related to SARS-CoV-2 has been isolated from Malayan pangolins illegally imported into Guangdong province. It is not the precursor of SARS-CoV-2, but comparison of viral genome sequences provides further evidence that the virus currently infecting humans was not produced in a laboratory. There are two important sequences in the viral spike glycoprotein (pictured) …
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Click arrow to play Download TWiV 537 (63 MB .mp3, 104 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Click arrow to play Download TWiV 534 (57 MB .mp3, 95 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Virus infections initiate when virions bind to receptors on the cell surface. It is well known that cells can be made susceptible to infection by providing DNA encoding the virus receptor. For example, mice cannot be infected with poliovirus, but become susceptible if they are given the human poliovirus receptor gene. Now we have learned that providing the receptor protein …
On episode #5 of the science show This Week in Evolution, Sara Sawyer and Kartik Chandran join Nels and Vincent to talk about how the filovirus receptor NPC1 regulates Ebolavirus susceptibility in bats. You can find TWiEVO #5 at microbe.tv/twievo, or you can listen below. [powerpress url=”http://traffic.libsyn.com/twievo/TWiEVO005.mp3″] Click arrow to play Download TWiEVO 5 (73 MB .mp3, 98 min) Subscribe (free): iTunes, RSS, email
On episode #363 of the science show This Week in Virology, The TWiVers reveal influenza virus replication in the ferret mammary gland and spread to a nursing infant, and selection of transmissible influenza viruses in the soft palate. You can find TWiV #363 at www.microbe.tv/twiv.