Dreaming of inactivated poliovirus vaccine

The World Health Organization’s global polio eradication effort uses the live, attenuated poliovirus vaccines developed by Albert Sabin. When the eradication program was announced in 1988, the goal was to eliminate global poliomyelitis, then cease immunization with poliovirus at some point in the future. In 2002 an outbreak of polio in the Dominican Republic sent …

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100th anniversary of the isolation of poliovirus

  Yesterday, 18 December, marked 100 years since Karl Landsteiner, MD and his assistant E. Popper, identified the viral etiologic agent of poliomyelitis. According to A History of Poliomyelitis by JR Paul:   …at a medical meeting in Vienna on December 18, 1908, the immunologist Landsteiner and his assistant Popper were able to demonstrate microscopic …

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New antiviral strategies

Vaccines have provided considerable success in preventing viral disease, but they have modest or no therapeutic effect for individuals who are already infected. Consequently, our second arm of antiviral defense has been the development and use of antiviral drugs: they can stop an infection once it has started. However, despite 50 years of research, our arsenal of antiviral drugs is dangerously …

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