Virology lecture #20: Vaccines
Download: .wmv (314 MB) | .mp4 (82 MB) Visit the virology W3310 home page for a complete list of course resources.
Download: .wmv (314 MB) | .mp4 (82 MB) Visit the virology W3310 home page for a complete list of course resources.
Hosts: Vincent Racaniello and Alan Dove. On episode #79 of the podcast “This Week in Virology”, Vincent and Alan converse about making published science accessible to everyone, global eradication of poliomyelitis, and whether a plant virus can cause disease in humans. This episode is sponsored by Data Robotics Inc. Use the promotion code TWIVPOD to …
Deep sequencing – which identified a viral contaminant of the rotavirus vaccine Rotarix – could have revealed the presence of simian virus 40 (SV40) in the poliovirus vaccine, had the technique been available in the 1950s. Exposure of over 100 million Americans to SV40, and many more worldwide, could have been avoided, as well as the debate …
The contamination of the rotavirus vaccine Rotarix with porcine circovirus 1 DNA was revealed by deep sequencing. The same technique was also used to demonstrate that oral poliovirus vaccine does not contain viruses that can cause poliomyelitis. The oral poliovirus vaccine strains developed by Albert Sabin (pictured) were licensed in the United States in 1962, …
No matter what advanced method is used to develop and produce vaccines, their efficacy is limited by old technology – the refrigerator. All viral vaccines must either be stored frozen, or kept at low temperatures. If they are not properly stored, they lose potency and do not confer protection against infection. The decay of vaccine …
Download: .wmv (324 MB) | .mp4 (76 MB) Visit the virology W3310 home page for a complete list of course resources.