Thirty years ago this month I did an experiment that set the course of my career, and provided an important step forward for animal virology. I showed that a cloned DNA copy of the poliovirus RNA genome is infectious in mammalian cells. When I arrived as a postdoctoral fellow in the laboratory of David Baltimore …
I joined Dr. Kirsten Sanford on episode 106 of Dr. Kiki’s Science Hour for a basic discussion about viruses. [powerpress url=”http://twit.cachefly.net/dksh0106.mp3″] Click the arrow above to play, or right-click to download DKSH #106 (31 MB .mp3, 64 minutes) Download video (272 MB .mp4)
Yesterday I terminated the last remaining mice in my small colony, including the line of poliovirus receptor transgenic mice that we established here in 1990. Remarkably, I had never written about this animal model for poliomyelitis which has played an important role in the work done in my laboratory. While I was still working on …
Analysis of poliovirus recovered from the stool of a patient with fatal poliomyelitis revealed that she had been infected with the virus 12 years earlier, probably when one of her children received the oral poliovirus vaccine. This case has the longest known incubation period for vaccine-derived poliomyelitis, and highlights our still rudimentary understanding of how …
Poliomyelitis after a twelve year incubation period Read More »
Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV127.mp3″] Click the arrow above to play, or right-click to download TWiV #127 (62 MB .mp3, …
On my recent trip to record TWiV #111 at Florida Gulf Coast University, I visited Rich Condit in Gainesville. There he told me a story about how the bacteriophage T7 polymerase/promoter system was developed. It’s an interesting tale that demonstrates how important scientific advances often have convoluted roots. You can watch the video below or …
