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TWiV 426: I’m Axl, and I’ll be your cervid today

1 Comment / This Week in Virology / By

The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells. You can find TWiV #426 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV426.mp3″] Click arrow to play Download TWiV 426 (66 MB .mp3, 110 min) Subscribe …

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TWiV 424: FLERVergnügen

1 Comment / This Week in Virology / By

Trudy joins the the TWiVlords to discuss new tests for detecting prions in the blood, and evidence showing that foamy retroviruses originated in the seas with their jawed vertebrate hosts at least 450 million years ago. You can find TWiV #424 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV424.mp3″] Click arrow to play Download TWiV 424 (67 MB .mp3, …

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A blood test for prion disease

2 Comments / Basic virology, Information / By

A sensitive and specific blood test has been developed that could be used to limit the risk of transmission of prion disease through the blood supply (link to papers one and two). Prion diseases, also known as spongiform encephalopathies, are uniformly fatal, chronic degenerative neurological diseases caused by misfolding of a cellular protein, PrPC. Transmissible …

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