pandemic

No evidence for increased human transmission of SARS-CoV-2

Don’t believe the headlines that SARS-CoV-2 is becoming more transmissible! Virologists are making conclusions that are not justified by the data. SARS-CoV-2 virus isolates from many parts of the world have a single amino acid change in the spike protein, D614G. This observation in itself doesn’t mean very much. It could be that the change …

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TWiV 637: Clearing the fog of ignorance

In this episode, approval of an Ad5 vectored SARS-CoV-2 vaccine for the military in China, description and clinical trials of a Novavax vaccine joining Operation Warp Speed, prevalence of SARS-CoV-2 in Spain, shedding and transmissibility of the virus, and listener email. Click arrow to playDownload TWiV 637 (66 MB .mp3, 109 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! …

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TWiV 635: Mask hysteria

Daniel Griffin provides a clinical update on COVID-19, then we review SARS-CoV-2 shedding in children, how to resume school safely, the need for widespread testing and wearing face masks, and much more, including listener email. Click arrow to playDownload TWiV 635 (92 MB .mp3, 153 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

Microneedle patch SARS-CoV-2 vaccine candidate

Most of the 172 SARS-CoV-2 vaccines in development will be administered by intramuscular injection, a traditional route for many effective vaccines. In my opinion the use of needles for immunization will one day be replaced by microneedle patches, which can not only be self-administered but have a variety of other advantages compared with injection. A …

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TWiV 631: Lots of eggs in the spike basket

Vincent, Rich, and Brianne discuss a study estimating the fraction of symptoms and severe disease after SARS- CoV-2 infection, cellular immune responses without seroconversion during interfamilial infections, and answer listener email. Click arrow to playDownload TWiV 631 (72 MB .mp3, 119 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv

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