multiplicity of infection

TWiV 521: Spitting in the Allee

Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”></span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;&lt;/span&gt; Click …

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Virology question of the week: What matters more, multiplicity of infection or virus concentration?

This week’s question comes from a graduate student studying virology, who writes: My professor recently said that really, the MOI doesn’t matter in a culture, it is the concentration of viral particles in the media that matters. Ie: if you have 10 million cells or one cell, but you are infecting the plate with 5mL …

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The Lazarus virus

There is an excellent question in the comments to “Are all virus particles infectious?“: if the particle-to-PFU ratio for a virus stock is 10,000:1, and I infect 1,000,000 cells with 10,000 particles, how many plaques would I expect to observe? Answering this question provides insight into the particle-to-PFU ratio of viruses. If we take 10,000 particles …

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TWiV 129: We’ve got mail

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, and Rich Condit Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV129.mp3″] Click the arrow above to play, or right-click to download …

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