TWiV minus one reveals delayed neurological deficits in children without microcephaly born to Zika virus infected mothers, and N-glycolyl-neuraminic acid as a receptor for influenza A viruses. Click arrow to play Download TWiV 556 (62 MB .mp3, 103 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Children who are exposed to Zika virus in utero may develop structural defects of the cranium such as microcephaly. Now we understand that even children born to Zika virus infected mothers may develop neurodevelopmental and neurosensory deficiencies in the second year of life – in the absence of microcephaly. During the 2015-16 Zika virus epidemic …
By Gertrud U. Rey Zika virus (ZIKV) infection causes microcephaly in newborns and is causally associated with Guillian-Barré syndrome in adults. To date, there are no drugs available to prevent or treat ZIKV infection. ZIKV vaccine research is challenging because adult immunocompetent mice are resistant to ZIKV infection and disease.
Amy Rosenfeld joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures. <span data-mce-type=”bookmark” class=”mce_SELRES_start”></span> Click arrow to play Download TWiV 468 (66 MB .mp3, 107 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Written with Amy Rosenfeld, Ph.D. By infecting organotypic brain slice cultures from embryonic mice, we have shown that Zika virus has always been neurotropic. The same culture system provides information on how Zika virus infection of the developing brain might lead to microcephaly.
Written with Amy Rosenfeld, Ph.D. Zika virus has been infecting humans since at least the 1950s (and probably earlier), but epidemics of infection have only been observed in the past ten years and congenital Zika syndrome in the last two. Two hypotheses emerged to explain this new pattern of disease: evolution of the virus, or …