influenza

TWiV 480: The PFU in your achoo

3 Comments / This Week in Virology / By Vincent Racaniello

Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”>ï»¿</span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”>ï»¿</span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;ï»¿&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” style=”display: …

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A breath of fresh influenza virus

3 Comments / Basic virology, Information / By Vincent Racaniello

Influenza virus may be transmitted among humans in three ways: by direct contact with infected individuals; by contact with contaminated objects (called fomites, such as toys, doorknobs); and by inhalation of virus-laden aerosols. A recent study suggests that normal tidal breathing plays a substantial role in aerosol transmission.

TWiV 441: Don’t ChrY for me influenza

1 Comment / This Week in Virology / By Vincent Racaniello

The Beacons of Viral Education (aka the TWiVoners) reveal a cost of being a male mouse – the Y chromosome regulates their susceptibility to influenza virus infection. You can find TWiV #441 at microbe.tv/twiv, or listen below. Click arrow to play Download TWiV 441 (72 MB .mp3, 119 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

Flu and the Y chromosome

3 Comments / Basic virology, Information / By Vincent Racaniello

Disease and death caused by influenza virus are greater in human females than in males. But disease is more common in males from birth through age 15, after which more females are affected. In mice, genetic variation in the Y chromosome controls susceptibility to influenza virus infection (link to paper). Increased susceptibility does not correlate …

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Paradoxical vaccines

3 Comments / Basic virology, Information / By Vincent Racaniello

A new breed of vaccines is on the horizon: they replicate in one type of cell, allowing for their production, but will not replicate in humans. Two different examples have recently been described for influenza and chikungunya viruses. The influenza virus vaccine is produced by introducing multiple amber (UAG) translation stop codons in multiple viral genes. …

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TWiV 420: Orthogonal vectors

1 Comment / This Week in Virology / By Vincent Racaniello

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines. You can find TWiV #420 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV420.mp3″] Click arrow to play Download TWiV 420 (70 MB .mp3, 116 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!

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