The results of experiments comparing the virulence in animals of the 2009 H1N1 influenza virus with seasonal strains have spawned the headline Study Suggests H1N1 Virus More Dangerous Than Suspected. In my view, the best experiment is now being done in humans: infection of millions with the pandemic virus. The results show that the virus …
Is the 2009 H1N1 influenza virus more dangerous than we think? Read More »
The plaque assay is a terrific method for determining virus titers, but it doesn’t work for all viruses. Fortunately there are several alternative methods available, including the end-point dilution assay. The end-point dilution assay was used to measure virus titer before the development of the plaque assay, and is still used for viruses that do …
Measurement of viruses by end-point dilution assay Read More »
Hosts: Vincent Racaniello, Dick Despommier, and Alan Dove On episode #40 of the podcast “This Week in Virology”, Vincent, Dick, and Alan consider Reston ebolavirus in swine, historical perspective of H1N1 influenza virus emergence and circulation, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, transmission of H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 …
Tamiflu (Oseltamivir) is one of the few antiviral drugs available for treatment of influenza. Use of the drug has increased substantially because of the emergence of the 2009 H1N1 pandemic strain, against which no vaccine is yet available. A recent study has shown that low levels of oseltamivir can be detected in the aquatic environment. …
Hosts: Vincent Racaniello and Dick Despommier On episode #39 of the podcast “This Week in Virology”, Vincent and Dick discuss virus structure and answer listener questions. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV039.mp3″] Click the arrow above to play, or right-click to download TWiV #39 (37 MB .mp3, 53 minutes) Subscribe to TWiV in iTunes, by the RSS feed, or by email Links …
The immune response to viral infection comprises innate and adaptive defenses. The innate response, which we have discussed previously, functions continuously in a normal host without exposure to any virus. Most viral infections are controlled by the innate immune system. However, if viral replication outpaces innate defenses, the adaptive response must be mobilized. The adaptive …
