inflammasome

TWiV 382: Everyone’s a little bit viral

This Week in Virology / By

On episode #382 of the science show This Week in Virology, Nels Elde and Ed Chuong join the TWiV team to talk about their observation that regulation of the human interferon response depends on regulatory sequences that were co-opted millions of years ago from endogenous retroviruses. You can find TWiV #382 at microbe.tv/twiv, or listen below. [powerpress …

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The inflammatory response

13 Comments / Basic virology, Information / By

During the earliest stages of a virus infection, cytokines are produced when innate immune defenses are activated. The rapid release of cytokines at the site of infection initiates new responses with far-reaching consequences that include inflammation. One of the earliest cytokines produced is tumor necrosis factor alpha (TNF-α), which is synthesized by activated monocytes and …

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