immune memory

How vaccines work

Vaccines work by educating the host’s immune system to recall the identity of a virus years after the initial encounter, a phenomenon called immune memory. Viral vaccines establish immunity and memory without the pathogenic consequences typical of a natural infection. The success of immunization in stimulating long-lived immune memory is among humanity’s greatest scientific and …

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TWiV 684: Persistence of SARS-CoV-2 immune memory

Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Click arrow to playDownload TWiV 684 (110 MB .mp3, 184 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at

TWiV 677: Does antibody really know what time it is?

Daniel Griffin provides a clinical report on COVID-19, then we discuss rapid deployment of SARS-CoV-2 testing by research laboratories in San Francisco, longitudinal observation of antibodies to SARS-CoV-2 in patients, and listener questions on vaccines, loss of smell, face masks, and more. Click arrow to playDownload TWiV 677 (97 MB .mp3, 162 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Become …

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Adaptive immune defenses: Antibodies

With the looming prospect of mass immunization against influenza, it’s important to understand how vaccines work. To do this we must have a good understanding of adaptive immune defenses. Today we’ll begin a discussion of the humoral arm of the adaptive immune response – antibodies. Antibodies are large proteins produced by vertebrates that play important …

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Adaptive immune defenses

The immune response to viral infection comprises innate and adaptive defenses. The innate response, which we have discussed previously, functions continuously in a normal host without exposure to any virus. Most viral infections are controlled by the innate immune system. However, if viral replication outpaces innate defenses, the adaptive response must be mobilized. The adaptive …

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