The retrovirus XMRV arose during passage of a human prostate tumor in nude mice. The genomes of these mice contain two different proviral DNAs related to XMRV, pre-XMRV-1 and pre-XMRV-2, that recombined to produce XMRV that has been isolated from humans. Two other prostate cancer cell lines also contain mouse gammaretroviruses that are not XMRV. These viruses …
Murine gammaretroviruses in prostate cancer cell lines Read More »
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Stephen Goff Retrovirologist Stephen Goff joins Vincent, Rich, and Alan for a discussion of recent papers on the retrovirus XMRV and its association with chronic fatigue syndrome and prostate cancer. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV136.mp3″] Click the arrow above to play, or right-click to download TWiV #136 (61 MB .mp3, 84 minutes). …
The first detailed study of infection of nonhuman primates with the retrovirus XMRV reveals that the virus establishes a persistent infection characterized by infection of multiple tissues. Viremia (virus in the blood) is low and transient, with proviral DNA detectable in blood lymphocytes. The results show that the Rhesus macaque can be used to study …
